BibTeX
@MISC{Serghides11therapyfor,
author = {Lena Serghides},
title = {Therapy for Cerebral Malaria},
year = {2011}
}
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Abstract
Copyright © 2012 Lena Serghides. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cerebral malaria is a severe complication of Plasmodium falciparum infection associated with high mortality even when highly effective antiparasitic therapy is used. Adjunctive therapies that modify the pathophysiological processes caused by malaria are a possible way to improve outcome. This review focuses on the utility of PPARγ agonists as an adjunctive therapy for the treatment of cerebral malaria. The current knowledge of PPARγ agonist use in malaria is summarized. Findings from experimental CNS injury and disease models that demonstrate the potential for PPARγ agonists as an adjunctive therapy for cerebral malaria are also discussed. 1.
Keyphrases
cerebral malaria adjunctive therapy ppar agonist disease model creative common attribution license original work effective antiparasitic therapy severe complication unrestricted use high mortality current knowledge open access article pathophysiological process possible way lena serghides plasmodium falciparum infection experimental cns injury ppar agonist use
