DMCA
The plasticity of aging: insights from long-lived mutants (2005)
| Venue: | Cell |
| Citations: | 236 - 6 self |
BibTeX
@ARTICLE{Kenyon05theplasticity,
author = {Cynthia Kenyon},
title = {The plasticity of aging: insights from long-lived mutants},
journal = {Cell},
year = {2005},
pages = {449--460}
}
Share
 |
 |
 |
 |
||
OpenURL
Abstract
Mutations in genes affecting endocrine signaling, stress responses, metabolism, and telomeres can all increase the life spans of model organisms. These mutations have revealed evolutionarily conserved pathways for aging, some of which appear to extend life span in response to sensory cues, caloric restric-tion, or stress. Many mutations affecting longevity pathways delay age-related disease, and the molecu-lar analysis of these pathways is leading to a mechanistic understanding of how these two processes— aging and disease susceptibility—are linked.
