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Review Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression (2007)
| Citations: | 10 - 0 self |
BibTeX
@MISC{Mann07reviewactivation,
author = {Giovanni E. Mann and David J. Rowl and Francois Y. L. Li and Patricia De Winter and Richard C. M. Siow},
title = {Review Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression},
year = {2007}
}
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Abstract
Time for primary review 20 days The endothelium plays a key role in the maintenance of vascular homeostasis, and increased oxidative stress in vascular disease leads to reduced nitric oxide bioavailability and impaired endothelium-dependent relaxation of resistance vessels. Although epidemiological evidence suggests that diets containing high amounts of natural antioxidants afford protection against coronary heart disease (CHD), antioxidant supplementation trials have largely reported only marginal health benefits. There is controversy concerning the cardiovascular benefits of prolonged estrogen/progestin or soy isoflavone therapy for postmenopausal women and patients with an increased risk of CHD. Research on the potential health benefits of soy isoflavones and other polyphenols contained in red wine, green and black tea and dark chocolate developed rapidly during the 1990's, and recent clinical trials and studies in animal models and cultured endothelial cells provide important and novel insights into the mechanisms by which dietary polyphenols afford protection against oxidative stress. In this review, we highlight that NO and reactive oxygen radicals may mediate dietary polyphenol induced activation of Nrf2, which in turn triggers antioxidant response
Keyphrases
review activation dietary isoflavones nrf2-mediated antioxidant gene expression oxidative stress oxygen radical vascular disease endothelial cell resistance vessel soy isoflavones prolonged estrogen progestin novel insight impaired endothelium-dependent relaxation antioxidant supplementation trial dietary polyphenols afford protection high amount dark chocolate key role turn trigger isoflavone therapy recent clinical trial animal model black tea nitric oxide bioavailability epidemiological evidence marginal health benefit postmenopausal woman dietary polyphenol potential health benefit cardiovascular benefit primary review vascular homeostasis natural antioxidant afford protection red wine coronary heart disease
