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Actin cytoskeletal dynamics in T lymphocyte activation and migration (2003)
| Venue: | Journal of Leukocyte Biology |
| Citations: | 14 - 1 self |
BibTeX
@ARTICLE{Samstag03actincytoskeletal,
author = {Yvonne Samstag and Sybille M. Eibert and Martin Klemke and Guido H. Wabnitz},
title = {Actin cytoskeletal dynamics in T lymphocyte activation and migration},
journal = {Journal of Leukocyte Biology},
year = {2003},
pages = {30--48}
}
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Abstract
Abstract: Dynamic rearrangements of the actin cytoskeleton are crucial for the function of numerous cellular elements including T lymphocytes. They are required for migration of T lymphocytes through the body to scan for the presence of antigens, as well as for the formation and stabilization of the immunological synapse at the interface between antigen-presenting cells and T lymphocytes. Supramolecular activation clusters within the immunological synapse play an important role for the initiation of T cell responses and for the execution of T cell effector functions. In addition to the T cell receptor/CD3 induced actin nucleation via Wasp/ Arp2/3-activation, signals through accessory receptors of the T cell (i.e., costimulation) regulate actin cytoskeletal dynamics. In this regard, the actin-binding proteins cofilin and L-plastin represent prominent candidates linking accessory receptor stimulation to the rearrangement of the actin cytoskeleton. Cofilin enhances actin polymerization via its actin-severing activity, and as a longlasting effect, cofilin generates novel actin monomers through F-actin depolymerization. L-plastin stabilizes actin filament structures by means of its
Keyphrases
actin cytoskeletal dynamic immunological synapse actin cytoskeleton important role accessory receptor stimulation actin nucleation actin monomer actin-severing activity cell effector function cell response actin polymerization prominent candidate antigen-presenting cell l-plastin stabilizes actin filament structure wasp arp2 3-activation regulate actin cytoskeletal dynamic actin-binding protein cofilin longlasting effect cofilin generates accessory receptor f-actin depolymerization dynamic rearrangement supramolecular activation cluster numerous cellular element cell receptor cd3
