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ERK/p90 RSK /14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa
| Citations: | 11 - 4 self |
BibTeX
@MISC{Dissanayake_erk/p90rsk,
author = {Kumara Dissanayake and Rachel Toth and Jamie Blakey and Olof Olsson and David G. Campbell and Alan R. Prescott and Carol Mackintosh},
title = {ERK/p90 RSK /14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa},
year = {}
}
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Abstract
Compounds that inhibit signalling upstream of ERK (extracellular-signal-regulated kinase) are promising anticancer therapies, motivating research to define how this pathway promotes cancers. In the present study, we show that human capicúa represses mRNA expression for PEA3 (polyoma enhancer activator 3) Ets transcription factors ETV1, ETV4 and ETV5 (ETV is Ets translocation variant), and this repression is relieved by multisite controls of capicúa by ERK, p90RSK (p90 ribosomal S6 kinase) and 14-3-3 proteins. Specifically, 14-3-3 binds to p90RSK-phosphorylated Ser173 of capicúa thereby modulating DNA binding to its HMG (high-mobility group) box, whereas ERK phosphorylations prevent binding of a C-terminal NLS (nuclear localization sequence) to importin α4 (KPNA3). ETV1,
Keyphrases
transcriptional repressor capic pea3 ets transcription factor erk p90 rsk 14-3-3 signalling 14-3-3 protein p90rsk-phosphorylated ser173 dna binding ets transcription factor etv1 polyoma enhancer activator present study extracellular-signal-regulated kinase c-terminal nls high-mobility group anticancer therapy 14-3-3 bind multisite control nuclear localization sequence p90 ribosomal s6 kinase human capic erk phosphorylations ets translocation variant
