Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein (2000)
| Venue: | J. Cell |
| Citations: | 22 - 0 self |
BibTeX
@ARTICLE{Koch00lessonsfrom,
author = {Peter J. Koch and Pierre A. De Viragh and Elisabeth Scharer and Donnie Bundman and Mary Ann Longley and Jackie Bickenbach and Yasuhiro Kawachi and Yasushi Suga and Zhijian Zhou and Marcel Huber and Daniel Hohl and Tonja Kartasova and Michal Jarnik and Alasdair C. Steven and Dennis R. Roop},
title = {Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein},
journal = {J. Cell},
year = {2000},
pages = {151--389}
}
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Abstract
Abstract. The epidermal cornified cell envelope (CE) is a complex protein–lipid composite that replaces the plasma membrane of terminally differentiated keratinocytes. This lamellar structure is essential for the barrier function of the skin and has the ability to prevent the loss of water and ions and to protect from environmental hazards. The major protein of the epidermal CE is loricrin, contributing �70 % by mass. We have generated mice that are deficient for this protein. These mice showed a delay in the formation of the skin barrier in embryonic development. At birth, homozygous mutant mice weighed less than control littermates and showed skin abnormalities, such as congenital erythroderma with a shiny, translucent skin. Tape stripping experiments suggested that the stratum corneum stability was
Keyphrases
envelope protein skin barrier function loricrin-deficient mouse compensatory mechanism translucent skin skin barrier cell envelope epidermal ce stratum corneum stability embryonic development control littermates complex protein environmental hazard lamellar structure major protein skin abnormality homozygous mutant mouse plasma membrane congenital erythroderma
