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AM. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 2008;4:e1000041
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| Venue: | A, Malloy MJ, Pullinger CR, Kane JP, Saccone S, Worthington J, Bruce I, Kwok PY, Menter A, Krueger J, Barton A, Saccone NL, Bowcock |
| Citations: | 51 - 3 self |
BibTeX
@ARTICLE{Liu_am.a,
author = {Ying Liu and Cynthia Helms and Wilson Liao and Lisa C. Zaba and Shenghui Duan and Jennifer Gardner and Carol Wise and Andrew Miner and M. J. Malloy and Clive R. Pullinger and John P. Kane and Scott Saccone and Jane Worthington and Alan Menter and James Krueger and Anne Barton and Nancy L. Saccone and Anne M},
title = {AM. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 2008;4:e1000041},
journal = {A, Malloy MJ, Pullinger CR, Kane JP, Saccone S, Worthington J, Bruce I, Kwok PY, Menter A, Krueger J, Barton A, Saccone NL, Bowcock},
year = {}
}
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Abstract
A genome-wide association study was performed to identify genetic factors involved in susceptibility to psoriasis (PS) and psoriatic arthritis (PSA), inflammatory diseases of the skin and joints in humans. 223 PS cases (including 91 with PSA) were genotyped with 311,398 single nucleotide polymorphisms (SNPs), and results were compared with those from 519 Northern European controls. Replications were performed with an independent cohort of 577 PS cases and 737 controls from the U.S., and 576 PSA patients and 480 controls from the U.K.. Strongest associations were with the class I region of the major histocompatibility complex (MHC). The most highly associated SNP was rs10484554, which lies 34.7 kb upstream from HLA-
