Genetic disorder or toxoplasma myocarditis: a case report of dilated cardiomyopathy with hypertrabeculation in a young asymptomatic woman
BibTeX
@MISC{M_geneticdisorder,
author = {Dobranici M and Buzea A and Popescu R and Chirila L},
title = {Genetic disorder or toxoplasma myocarditis: a case report of dilated cardiomyopathy with hypertrabeculation in a young asymptomatic woman},
year = {}
}
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Abstract
Isolated noncompaction of the left ventricle (LV) is a rare disorder, classified as a primary genetic cardiomyopathy by the American Heart Association. The European Society of Cardiology Working Group on Myocardial and Pericardial Diseases classified LV noncompaction as an unclassified cardiomyopathy. LV noncompaction cardiomyopathy characterized by the following features: 1) an altered myocardial wall with prominent trabeculae and deep intertrabecular recesses resulting in thickened myocardium with two layers, consisting of compacted and noncompacted myocardium and 2) continuity between the left ventricular cavity and the deep intertrabecular recesses, which are filled with blood from the ventricular cavity, without evidence of communication with the epicardial coronary artery system. Features of LV noncompaction can overlap with dilated cardiomyopathy, hypertrophic cardiomyopathy (especially the apical variant), and restrictive cardiomyopathy. The phenotypic expression can vary considerably within the same family. The LV noncompaction can rarely occur as a transient phenomenon during myocarditis. We present the case of a 23-year-old patient, admitted to our Department for cardiac evaluation because of ECG changes and cardiac enlargement revealed at thoracic radiography. She had a history of chronic toxoplasmosis. An echocardiography was performed revealing left ventricular enlargement with severe systolic and diastolic dysfunction, diffuse hypokinesia and signs of isolated left ventricular non-compaction. Under these circumstances, we have considered the presence of isolated left ventricular non-compaction. A cardiac Magnetic Resonance Imaging was performed and it sustained the diagnosis. The alternative cause of
Keyphrases
lv noncompaction toxoplasma myocarditis genetic disorder case report young asymptomatic woman deep intertrabecular recess ventricular non-compaction primary genetic cardiomyopathy cardiology working group transient phenomenon hypertrophic cardiomyopathy unclassified cardiomyopathy pericardial disease chronic toxoplasmosis diastolic dysfunction restrictive cardiomyopathy lv noncompaction cardiomyopathy following feature cardiac enlargement thickened myocardium phenotypic expression severe systolic dilated cardiomyopathy ventricular cavity diffuse hypokinesia myocardial wall 23-year-old patient cardiac magnetic resonance imaging isolated noncompaction left ventricular cavity ventricular enlargement prominent trabecula left ventricle epicardial coronary artery system cardiac evaluation apical variant ecg change european society american heart association alternative cause thoracic radiography rare disorder
