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Mutagenesis: ILP experiments in a non-determinate biological domain (1994)
| Venue: | Proceedings of the 4th International Workshop on Inductive Logic Programming, volume 237 of GMD-Studien |
| Citations: | 110 - 11 self |
BibTeX
@INPROCEEDINGS{Muggleton94mutagenesis:ilp,
author = {Srinivasan And Muggleton and A. Srinivasan and S. H. Muggleton},
title = {Mutagenesis: ILP experiments in a non-determinate biological domain},
booktitle = {Proceedings of the 4th International Workshop on Inductive Logic Programming, volume 237 of GMD-Studien},
year = {1994},
pages = {217--232}
}
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Abstract
This paper describes the use of Inductive Logic Programming as a scientific assistant. In particular, it details the application of the ILP system Progol to discovering structural features that can result in mutagenicity in small molecules. To discover these concepts, Progol only had access to the atomic and bond structure of the molecules. With such a primitive description and no further assistance from chemists, Progol corroborated some existing knowledge and proposed a new structural alert for mutagenicity in compounds. In the process, the experiments act as a case study in which, even with extremely limited background knowledge, an Inductive Logic Programming tool firstly, complements a complex statistical model developed by skilled chemists, and secondly, continues to provide understandable theories when the statistical model fails. The experiments also constitute the first demonstrations of a prototype of the Progol system. Progol allows the construction of hypotheses with bounded non-determinacy by performing a best-first search within the subsumption lattice. The results here provide evidence that such searches are both viable and desirable. 1
Keyphrases
non-determinate biological domain ilp experiment structural feature bond structure small molecule inductive logic programming tool inductive logic programming case study complex statistical model primitive description understandable theory subsumption lattice best-first search ilp system progol skilled chemist experiment act limited background knowledge progol system statistical model fails new structural alert scientific assistant first demonstration
