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Sequence Logos: A New Way to Display Consensus Sequences (1990)
| Venue: | Nucleic Acids Res |
| Citations: | 648 - 28 self |
BibTeX
@ARTICLE{Schneider90sequencelogos:,
author = {homas D. Schneider and Thomas D. Schneider and R. Michael Stephens},
title = {Sequence Logos: A New Way to Display Consensus Sequences},
journal = {Nucleic Acids Res},
year = {1990},
volume = {18},
pages = {6097--6100}
}
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Abstract
INTRODUCTION A logo is "a single piece of type bearing two or more usually separate elements" [1]. In this paper, we use logos to display aligned sets of sequences. Sequence logos concentrate the following information into a single graphic [2]: 1. The general consensus of the sequences. National Cancer Institute, Frederick Cancer Research and Development Center, Laboratory of Mathematical Biology, P. O. Box B, Frederick, MD 21701. Internet addresses: toms@ncifcrf.gov and stephens@ncifcrf.gov. y corresponding author 1 2. The order of predominance of the residues at every position. 3. The relative frequencies of every residue at every position. 4. The amount of information present at every position in the sequence, measured in bits. 5. An initiation point, cut point, or other significant location (if appropriate) . Any aligned set of DNA, RNA or protein sequences can be represented using this technique. CREATION OF BINDING S
Keyphrases
sequence logo display consensus sequence new way aligned set general consensus development center separate element following information national cancer institute internet address mathematical biology introduction logo type bearing frederick cancer research information present significant location protein sequence relative frequency single piece initiation point
