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Modeling the Effects of Dopamine on the Antisaccade Reaction Times (aSRT) of Schizophrenia Patients
BibTeX
@MISC{Cutsuridis_modelingthe,
author = {Vassilis Cutsuridis and Ioannis Kahramanoglou and Nikolaos Smyrnis and Ioannis Evdokimidis and Stavros Perantonis},
title = {Modeling the Effects of Dopamine on the Antisaccade Reaction Times (aSRT) of Schizophrenia Patients},
year = {}
}
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Abstract
Abstract. In the antisaccade task, subjects are instructed to look in the opposite direction of a visually presented stimulus. Controls can perform this task successfully with very few errors, whereas schizophrenia patients make more errors and their responses are slower and more variable. It has been proposed the fundamental cognitive dysfunction in schizophrenia involves prefrontal dopaminergic hypoactivity. We examine via computer simulations the effects of dopamine on the variability of aSRTs in a neural cortico-collicular accumulator model with stochastic climbing activity. We report the simulated aSRTs for the hypo-DA level have higher standard deviation and mean values than in the normal and hyper DA level. The simulated higher mean and standard deviation for the hypo-DA group resemble the performance differences in the antisaccade task observed in patients with schizophrenia and are in accordance with the theory of a hypo-DA state in the frontal cortical areas of patients with schizophrenia.
Keyphrases
antisaccade reaction time schizophrenia patient antisaccade task standard deviation schizophrenia involves prefrontal dopaminergic hypoactivity neural cortico-collicular accumulator model simulated asrts fundamental cognitive dysfunction hypo-da group hypo-da state opposite direction computer simulation hypo-da level mean value hyper da level performance difference frontal cortical area
