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Relating Whole-Genome Expression Data with Protein-Protein Interactions (2002)
| Citations: | 229 - 14 self |
BibTeX
@MISC{Jansen02relatingwhole-genome,
author = {Ronald Jansen and Dov Greenbaum and Mark Gerstein},
title = {Relating Whole-Genome Expression Data with Protein-Protein Interactions},
year = {2002}
}
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Abstract
this paper is the interactions occurring within specific complexes. These were obtained from the MIPS complexes catalog (Fellenberg et al. 2000), which represents a carefully annotated, comprehensive data set of protein complexes culled from the scientific literature. In addition, we looked at other types of protein-protein interactions from large "aggregated" data sets collecting many heterogeneous pair-wise interactions. We collected these from the MIPS catalogs of physical and genetic interactions (Fellenberg et al. 2000), databases of interacting proteins (DIP and BIND) (Bader and Hogue 2000; Xenarios 2000), and a comprehensive collection of yeast two-hybrid experiments (Cagney et al. 2000; lto et al. 2000; Schwikowski et al. 2000; Uetz et al. 2000; Uetz and Hughes 2000; lto et al. 2001). These interactions are subdivided into groups based on their method of discovery. They include physical interactions (e.g., collected through coimmunoprecipitation and copurification), genetic interactions (e.g., determined through genetic means such as synthetic lethality or suppression experiments), and yeast twohybrid pairs
Keyphrases
protein-protein interaction whole-genome expression data genetic interaction suppression experiment synthetic lethality protein complex specific complex many heterogeneous pair-wise interaction twohybrid pair comprehensive data set comprehensive collection scientific literature mips catalog data set genetic mean physical interaction mips complex catalog yeast two-hybrid experiment
