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The scanning model for translation: An update (1989)
| Venue: | J Cell Biol |
| Citations: | 496 - 0 self |
BibTeX
@ARTICLE{Kozak89thescanning,
author = {Marilyn Kozak},
title = {The scanning model for translation: An update},
journal = {J Cell Biol},
year = {1989},
volume = {108},
pages = {229--241}
}
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Abstract
Abstract. The small (40S) subunit of eukaryotic ribo-somes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but T HE scanning mechanism for initiation of translation in eukaryotes was proposed 10 years ago (112). Support-ing evidence has accumulated at a slower rate than one might have wished, but a trickle sustained over 10 yr forms a decent-sized pond. Some remarkable experiments now be-ing carried out in yeasts are yielding important new insights about scanning and other aspects of initiation, and the power of the yeast system promises additional breakthroughs in the coming years. Thus, it seems a good time to review what
