ACKNOWLEDGEMENTS

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ACKNOWLEDGEMENTS

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by Li Huihua , Supervisor Graham , J. L. Kemp

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@MISC{Huihua_acknowledgements,
    author = {Li Huihua and Supervisor Graham and J. L. Kemp},
    title = {ACKNOWLEDGEMENTS},
    year = {}
}

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Abstract

Graham J.L. Kemp, to whom I would like to express my deep gratitude for his advice, guidance and encouragement. I benefited a lot from close collaboration with him. I would also thank other teachers and students in our program for their help and encouragement. II A database of antibody sequences and structures was built in an earlier project [Kemp et al., 1994]. That database contained indexes that made it easy to find residues at structurally equivalent positions in different domains, thus making it convenient to explore structural hypotheses. However, constructing these indexes by hand was a slow and inconvenient process, so we now seek to automate this task as we extend the database to include additional immunoglobulin domains. Earlier structural studies of antibody VH and VL variable domains [Chothia and Lesk, 1987] and T-cell receptor variable domains [Chothia et al., 1988] identified template β − sheet framework patterns based on conserved main chain hydrogen bond

Keyphrases

t-cell receptor variable domain additional immunoglobulin domain equivalent position inconvenient process antibody vh graham j.l. kemp close collaboration structural hypothesis different domain template sheet framework pattern antibody sequence structural study vl variable domain conserved main chain hydrogen bond deep gratitude project kemp

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