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A gene-coexpression network for global discovery of conserved genetic modules (2003)
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| Venue: | Science |
| Citations: | 377 - 5 self |
BibTeX
@ARTICLE{Stuart03agene-coexpression,
author = {Joshua M. Stuart and Eran Segal and Daphne Koller and Stuart K. Kim},
title = {A gene-coexpression network for global discovery of conserved genetic modules},
journal = {Science},
year = {2003},
volume = {302},
pages = {249--255}
}
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Abstract
To elucidate gene function on a global scale, we identified pairs of genes that are coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found 22,163 such coexpression relationships, each of which has been conserved across evolution. This conservation implies that the coexpression of these gene pairs confers a selective advantage and therefore that these genes are functionally related. Manyof these relationships provide strong evidence for the involvement of new genes in core biological functions such as the cell cycle, secretion, and protein expression. We experimentallyconfirmed the predictions implied bysome of these links and identified cell proliferation functions for several genes. By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules. The genome sequences of humans and several model organisms have established a nearly complete list of the genes required to
Keyphrases
gene-coexpression network global discovery conserved genetic module gene function cell proliferation function complete list several model organism global scale dna microarrays protein expression strong evidence core biological function genome sequence coexpression relationship cell cycle new gene selective advantage several component ancient module several gene
