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Structural bioinformatics Advance Access publication April 28, 2010 Modeling RNA loops using sequence homology and geometric constraints (2010)
BibTeX
@MISC{Schudoma10structuralbioinformatics,
author = {Christian Schudoma and Patrick May and Dirk Walther and Ivo Hofacker},
title = {Structural bioinformatics Advance Access publication April 28, 2010 Modeling RNA loops using sequence homology and geometric constraints},
year = {2010}
}
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Abstract
Summary: RNA loop regions are essential structural elements of RNA molecules influencing both their structural and functional properties. We developed RLooM, a web application for homology-based modeling of RNA loops utilizing template structures extracted from the PDB. RLooM allows the insertion and replacement of loop structures of a desired sequence into an existing RNA structure. Furthermore, a comprehensive database of loops in RNA structures can be accessed through the web interface. Availability and Implementation: The application was implemented in Python, MySQL and Apache. A web interface to the database and loop modeling application is freely available at
