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Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genet 5 (2009)
| Citations: | 16 - 3 self |
BibTeX
@MISC{Barreiro09evolutionarydynamics,
author = {Luis B. Barreiro and Meriem Ben-ali and Hélène Quach and Guillaume Laval and Etienne Patin and Joseph K and Christiane Bouchier and Magali Tichit and Olivier Neyrolles and Brigitte Gicquel and Judith R. Kidd and Kenneth K. Kidd and Re Alcaïs and Josiane Ragimbeau and Ra Pellegrini and Laurent Abel},
title = {Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genet 5},
year = {2009}
}
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Abstract
Infectious diseases have been paramount among the threats to health and survival throughout human evolutionary history. Natural selection is therefore expected to act strongly on host defense genes, particularly on innate immunity genes whose products mediate the direct interaction between the host and the microbial environment. In insects and mammals, the Tolllike receptors (TLRs) appear to play a major role in initiating innate immune responses against microbes. In humans, however, it has been speculated that the set of TLRs could be redundant for protective immunity. We investigated how natural selection has acted upon human TLRs, as an approach to assess their level of biological redundancy. We sequenced the ten human TLRs in a panel of 158 individuals from various populations worldwide and found that the intracellular TLRs—activated by nucleic acids and particularly specialized in viral recognition—have evolved under strong purifying selection, indicating their essential
Keyphrases
plo genet evolutionary dynamic different contribution human toll-like receptor natural selection intracellular tlrs strong purifying selection tolllike receptor major role various population worldwide protective immunity viral recognition innate immune response microbial environment biological redundancy human tlrs infectious disease host defense gene direct interaction innate immunity gene ten human tlrs human evolutionary history nucleic acid
