BibTeX
@MISC{Yu_newdevelopments,
author = {Fu-shin X. Yu and Linda D. Hazlett},
title = {NEW DEVELOPMENTS Toll-like Receptors and the},
year = {}
}
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Abstract
The immune response to microbial pathogens relies on both innate and adaptive components. 1 The innate or immediate response is mediated in large measure by leukocytes of the blood, such as neutrophils (PMNs) and macrophages, cells that phagocytose and kill the pathogens and that concurrently coordinate additional host responses by synthesis of a wide range of inflammatory mediators and cytokines. 2 A primary challenge to the innate immune system is the ability to discriminate among a large number of potential pathogens from self, with the use of a restricted number of receptors. This discrimination is achieved by the evolution of a variety of receptors that recognize conserved motifs on pathogens called pathogenassociated molecular patterns (PAMPs). Toll-like receptors (TLRs), perhaps the best-characterized class of pattern-recognition receptors (PRRs) 3,4 in mammalian species, play an important
Keyphrases
new development toll-like receptor large measure molecular pattern mammalian specie immediate response additional host response microbial pathogen relies inflammatory mediator pattern-recognition receptor primary challenge potential pathogen wide range best-characterized class adaptive component large number toll-like receptor immune response innate immune system restricted number
