DMCA
MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor (1999)
| Citations: | 201 - 17 self |
BibTeX
@MISC{Shimazu99md-2,a,
author = {Rintaro Shimazu and Sachiko Akashi and Hirotaka Ogata and Yoshinori Nagai and Kenji Fukudome and Kensuke Miyake and Masao Kimoto},
title = {MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor},
year = {1999}
}
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Abstract
Toll-like receptor 4 (TLR4) is a mammalian homologue of Drosophila Toll, a leucine-rich repeat molecule that can trigger innate responses against pathogens. The TLR4 gene has recently been shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS). TLR4 may be a long-sought receptor for LPS. However, transfection of TLR4 does not confer LPS responsiveness on a recipient cell line, suggesting a requirement for an additional molecule. Here, we report that a novel molecule, MD-2, is requisite for LPS signaling of TLR4. MD-2 is physically associated with TLR4 on the cell surface and confers responsiveness to LPS. MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms. Key words: leucine-rich repeat • RP105 • MD-1 • nuclear factor �B • signaling Exclusion of invading nonself pathogens is one of the basic homeostatic mechanisms for multicellular organisms. In organisms as divergent as plants, flies, and humans, leucine-rich repeat (LRR) 1 molecules have been implicated
Keyphrases
toll-like receptor novel molecule drosophila toll recipient cell line additional molecule long-sought receptor basic homeostatic mechanism new receptor complex leucine-rich repeat molecule multicellular organism c3h hej low responder leucine-rich repeat mammalian homologue innate response cell surface host defense key word tlr4 gene potential implication nonself pathogen
