DMCA
Chronic Stress and Susceptibility to Skin Cancer
BibTeX
@MISC{Saul_chronicstress,
author = {Alison N. Saul and Tatiana M. Oberyszyn and Christine Daugherty and Donna Kusewitt and Susie Jones and Scott Jewell and William B. Malarkey and Amy Lehman and Firdaus S. Dhabhar},
title = {Chronic Stress and Susceptibility to Skin Cancer},
year = {}
}
Share
 |
 |
 |
 |
||
OpenURL
Abstract
Background: Studies have shown that chronic stress or UV radiation independently suppress immunity. Given their in-creasing prevalence, it is important to understand whether and how chronic stress and UV radiation may act together to increase susceptibility to disease. Therefore, we investigated potential mediators of a stress-induced increase in emergence and progression of UV-induced squamous cell carcinoma. Methods: SKH1 mice susceptible to UV-induced tumors were unexposed (naïve, n = 4) or exposed ( n = 16) to 2240 J/m 2 of UVB radiation three times a week for 10 weeks. Half of the UVB-exposed mice were left nonstressed (i.e., they remained in their home cages) and the other half were chronically stressed (i.e., restrained during weeks 4 – 6). UV-induced tumors were measured weekly from week 11 through week 34, blood was collected at week 34, and tissues were collected
