BibTeX
@MISC{04effectof,
author = {},
title = {Effect of Methoxychlor on Various Life Stages of Xenopus laevis},
year = {2004}
}
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Abstract
The toxicological effects of the organochlorine pesticide methox-ychlor were evaluated at various life stages of the South African clawed frog,Xenopus laevis, in an effort to determine stage-specific sensitivity. A battery of four separate assays, including a short-term (4-day) early embryo-larval assay (FETAX) (NF stages 8–46 [Nieuwkoop and Faber, 1994]), 30-day hind limb development assay (NF stages 8–54), 18-day metamorphic climax assay (NF stages 58–66), and 30-day adult reproduction assaywere performed. Test concentrations for the FETAX, hind limb development, meta-morphic climax, and reproductive assays ranged from 0.0001– 1.0 mg/l, 0.0001–0.1 mg/l, 0.0001–0.1 mg/l, and 0.001–0.1 mg/l, respectively. Results from the short-term embryo-larval assay indi-cated that increased embryo-lethality, malformation, and growth inhibition were not induced at 1.0 mg/l methoxychlor (maximum soluble concentration). The 30-day hind limb development studies
Keyphrases
xenopus laevis various life stage growth inhibition test concentration hind limb development separate assay 18-day metamorphic climax maximum soluble concentration mg methoxychlor stage-specific sensitivity short-term embryo-larval assay early embryo-larval assay organochlorine pesticide methox-ychlor reproductive assay 30-day adult reproduction toxicological effect meta-morphic climax 30-day hind limb development assay 30-day hind limb development study
