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TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis -- A Genomewide Study
| Citations: | 83 - 1 self |
BibTeX
@MISC{Plenge_traf1–c5as,
author = {Robert M. Plenge and Mark Seielstad and Ph. D and Leonid Padyukov and Ph. D and Annette T. Lee and Ph. D and Elaine F. Remmers and Ph. D and Bo Ding and Ph. D and Anthony Liew and Houman Khalili and Alamelu Ch and Ph. D and Leela R. L. Davies and Evan M. Beckman and David Altshuler and Ph. D and Lars Alfredsson and Ph. D and Lindsey A. Criswell and Christopher I. Amos and Ph. D and Michael F. Seldin and Ph. D and Daniel L. Kastner and Ph. D and Lars Klareskog and Ph. D and Peter K. Gregersen},
title = { TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis -- A Genomewide Study},
year = {}
}
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Abstract
Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1 and PTPN22 are well-established susceptibility loci, other genes that confer a modest level of risk have been identified recently. We carried out a genomewide association analysis to identify additional genetic loci associated with an increased risk of rheumatoid arthritis. Methods We genotyped 317,503 single-nucleotide polymorphisms (SNPs) in a combined case– control study of 1522 case subjects with rheumatoid arthritis and 1850 matched control subjects. The patients were seropositive for autoantibodies against cyclic citrullinated peptide (CCP). We obtained samples from two data sets, the North American Rheumatoid Arthritis Consortium (NARAC) and the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA). Results from NARAC and EIRA for 297,086 SNPs that passed quality-control filters were combined with the use of Cochran– Mantel–Haenszel stratified analysis. SNPs showing a significant association with disease (P<1×10 −8) were genotyped in an independent set of case subjects with anti–
Keyphrases
rheumatoid arthritis traf1 c5 risk locus rheumatoid arthritis genomewide study control subject quality-control filter modest level significant association independent set cochran mantel haenszel additional genetic locus north american rheumatoid arthritis consortium swedish epidemiological investigation data set case subject well-established susceptibility locus genomewide association analysis single-nucleotide polymorphism combined case control study complex mode
