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Cerebellar Projections to the Prefrontal Cortex of the Primate
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BibTeX
@MISC{Middleton_cerebellarprojections,
author = {Frank A. Middleton and Peter L. Strick},
title = {Cerebellar Projections to the Prefrontal Cortex of the Primate},
year = {}
}
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Abstract
The cerebellum is known to project via the thalamus to multiple motor areas of the cerebral cortex. In this study, we examined the extent and anatomical organization of cerebellar input to multiple regions of prefrontal cortex. We first used conventional retrograde tracers to map the origin of thalamic projections to five prefrontal regions: medial area 9 (9m), lateral area 9 (9l), dorsal area 46 (46d), ventral area 46, and lateral area 12. Only areas 46d, 9m, and 9l received substantial input from thalamic regions included within the zone of termination of cerebellar efferents. This suggested that these cortical areas were the target of cerebellar output. We tested this possibility using retrograde transneuronal transport of the McIntyre-B strain of herpes simplex virus type 1 from areas of prefrontal cortex. Neurons labeled by retrograde transneuronal transport of virus were found in the dentate nucleus only after injections into
Keyphrases
prefrontal cortex cerebellar projection lateral area retrograde transneuronal transport anatomical organization substantial input cerebellar efferent motor area cerebral cortex herpes simplex virus type cerebellar input cortical area medial area dorsal area conventional retrograde tracer ventral area cerebellar output mcintyre-b strain thalamic projection thalamic region prefrontal region
