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Expression of the peroxisome proliferator-activated receptor � (PPAR�) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein (1998)
| Venue: | Proc. Natl. Acad. Sci. USA |
| Citations: | 266 - 7 self |
BibTeX
@ARTICLE{Ricote98expressionof,
author = {Mercedes Ricote and Jannet T. Huang and John S. Welch and Christopher K. Glass},
title = {Expression of the peroxisome proliferator-activated receptor � (PPAR�) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein},
journal = {Proc. Natl. Acad. Sci. USA},
year = {1998},
pages = {7614--7619}
}
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Abstract
(PPARs) are ligand-dependent transcription factors of the nuclear hormone receptor superfamily, which includes the steroid, retinoid, and thyroid hormone receptors. The PPARs can be activated by fatty acids and their eicosanoid metabolites, and have until recently been considered primarily to regulate genes involved in glucose and lipid homeostasis. In the past year there has been an explosive increase in research implicating PPAR� in macrophage biology, cell cycle regulation, and atherosclerosis. This review describes recent insights into the role of PPAR � in the macrophage lineage, and its potential function in the regulation of inflammatory responses and atherosclerosis. J. Leukoc. Biol. 66: 733–739; 1999.
Keyphrases
peroxisome proliferator-activated receptor colony stimulating factor low density lipoprotein human atherosclerosis recent insight lipid homeostasis potential function inflammatory response nuclear hormone receptor explosive increase macrophage biology macrophage lineage fatty acid hormone receptor ligand-dependent transcription factor past year cell cycle regulation eicosanoid metabolite
