Immunology of Staphylococcal Biofilm Infections in the Eye: New Tools to Study Biofilm Endophthalmitis
BibTeX
@MISC{Leid_immunologyof,
author = {Jeff G. Leid and J. W. Costerton and Mark E. Shirtliff and Michael S. Gilmore and Michael Engelbert},
title = {Immunology of Staphylococcal Biofilm Infections in the Eye: New Tools to Study Biofilm Endophthalmitis},
year = {}
}
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Abstract
Endophthalmitis is an important disease of the eye that is most frequently caused by postoperative and post-traumatic introduction of bacteria into the posterior segment of the eye. In the case of severe infections, vi-sual acuity is greatly damaged or completely lost. Much work has focused on the ability of planktonic bacte-ria to cause infection and ocular damage while little work has focused on chronic infections in endophthalmitis mediated by the formation of bacterial biofilms on the surface of the lens. This review focuses on the inter-action of Staphylococcus aureus and Staphylococcus epidermidis lens-associated biofilms in endophthalmitis. Additionally, this review highlights some relevant biofilm-immune system interactions and outlines a new in vivo mouse model to explore biofilm-related infections in endophthalmitis. 405
Keyphrases
staphylococcal biofilm infection new tool study biofilm endophthalmitis posterior segment post-traumatic introduction vi-sual acuity bacterial biofilms severe infection staphylococcus aureus important disease planktonic bacte-ria little work biofilm-related infection chronic infection vivo mouse model much work ocular damage relevant biofilm-immune system interaction lens-associated biofilms
