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The molecular weight of antibodies
| Venue: | J. Exp. Mad |
| Citations: | 6 - 0 self |
BibTeX
@ARTICLE{Heidelberger_themolecular,
author = {Michael Heidelberger and Ph. D and Kai and O. Pedersen and M. Sc},
title = {The molecular weight of antibodies},
journal = {J. Exp. Mad},
year = {},
pages = {393}
}
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Abstract
It is now generally accepted that antibodies are actually modified serum proteins. The work of Felton on the concentration and nature of pneumococcus antibodies (1) and a series of quantitative analytical studies on the precipitin reaction and its mechanism (.2) have contributed to the adoption of this conclusion, and have recently led to the isolation of serum protein fractions of which up to 98 per cent of the protein present could be accounted for as antibody by actual chemical analysis (3). The availability of material of such high antibody content suggested the present study. The determination of the molecular weight of antibodies is of interest in a number of connections. Knowledge of this constant would be expected to throw light on the relation of antibodies to normal serum proteins and on the mechanism of antibody formation. Such a study should also permit chemical formulas to be written for some of the limiting compounds formed in antigen-antibody combination, a subject which will be taken up in another communication. Finally, should differences be found in antibodies produced by different species of animals, this would not only be of physiological interest but might also be of importance for serum therapy. Preliminary studies on antibody particle size have already been reported (2d, 1 * The expenses of the present investigation were defrayed by the Harkness
Keyphrases
molecular weight present study pneumococcus antibody serum therapy serum protein chemical formula present investigation serum protein fraction high antibody content physiological interest quantitative analytical study normal serum protein preliminary study antibody formation antigen-antibody combination protein present different specie antibody particle size actual chemical analysis precipitin reaction
