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1 Cataloguing proteins in cell cycle control (2002)
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BibTeX
@MISC{Wrzeszczynski021cataloguing,
author = {Kazimierz O. Wrzeszczynski and Howard Lieberman and Kazimierz O Wrzeszczynski and Burkhard Rost},
title = {1 Cataloguing proteins in cell cycle control},
year = {2002}
}
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Abstract
Bioinformatics makes a number of methods available that can also be used to identify cell cycle related proteins. Nevertheless, few tools are specifically designed to cope with cell cycle proteins. In fact, a vast amount of data is currently scattered among many databases. Here, we present a first detailed analysis of known cell cycle proteins. We combined databases mining and literature searches with an evaluation of evolutionary conservation. The objective was to identify cell cycle control proteins in various proteomes. In total we found 595 experimentally annotated cell cycle control proteins; these clustered into 113 distinct structural families. We noticed that neither simple values for pairwise sequence identity nor expectation values taken from popular PSI-BLAST alignments allow an error-free
Keyphrases
cell cycle control distinct structural family pairwise sequence identity popular psi-blast alignment cell cycle related protein vast amount database mining various proteome literature search first detailed analysis cell cycle many database simple value expectation value cell cycle protein evolutionary conservation
