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A Review of Molecular Mechanisms of the Anti-Leukemic Effects of Phenolic Compounds in Honey (2012)
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@MISC{Abubakar12areview,
author = {Murtala B. Abubakar and Wan Zaidah Abdullah and Siti Amrah Sulaiman and Ang Boon Suen},
title = {A Review of Molecular Mechanisms of the Anti-Leukemic Effects of Phenolic Compounds in Honey},
year = {2012}
}
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Abstract
Abstract: Hematologic malignancies constitute about 9 % of all new cases of cancers as reported via the GLOBOCAN series by International Agency for Research on Cancer (IARC) in 2008. So far, the conventional therapeutic and surgical approaches to cancer therapy have not been able to curtail the rising incidence of cancers, including hematological malignancies, worldwide. The last decade has witnessed great research interest in biological activities of phenolic compounds that include anticancer, anti-oxidation and anti-inflammation, among other things. A large number of anticancer agents combat cancer through cell cycle arrest, induction of apoptosis and differentiation, as well as through inhibition of cell growth and proliferation, or a combination of two or more of these mechanisms. Various phenolic compounds from different sources have been reported to be promising anticancer agents by acting through one of these mechanisms. Honey, which has a long history of human consumption both for medicinal and nutritional uses, contains a variety of phenolic compounds such as flavonoids, phenolic acids, coumarins and tannins. This paper presents a review on the molecular mechanisms of the anti-leukemic activity of various phenolic compounds on cell cycle, cell growth and
Keyphrases
phenolic compound molecular mechanism anti-leukemic effect cell growth various phenolic compound human consumption cell cycle arrest hematological malignancy last decade large number promising anticancer agent international agency hematologic malignancy different source nutritional us cell cycle anticancer agent combat cancer globocan series anti-leukemic activity phenolic acid surgical approach long history biological activity new case cancer therapy great research interest
