BibTeX
@MISC{In_dispatchesrapid,
author = {Clindamycin In},
title = {Dispatches Rapid Increase of Resistance to},
year = {}
}
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Abstract
A survey of antibiotic resistance in Streptococcus pyogenes in Italy showed a sharp increase in erythromycin resistance. In 1993, the incidence of erythromycinresistant strains was on average 5.1%, with marked variations by geographic area. Two years later, the incidence of these strains had registered a 1.5- to roughly 20-fold increase, with a mean value of 25.9%, exceeding 40 % in three centers out of 13 and 30 % in another four. For all the strains studied, normal levels of susceptibility to penicillin were reported. Over the past few years, the increased frequency of infections caused by Streptococcus pyogenes (group A streptococcus [GAS]) and their sequelae has been reported in several parts of the world (1,2). Even though these reports may reflect an enhanced awareness of and interest in these possibly life-threatening infections on the part of the medical community (3), in at least some areas, an increase in severe infections over time has been documented (4,5). Meanwhile, the increased clinical use of erythromycin and its derivatives, mostly in upper respiratory tract infections, has been related to an increased resistance of GAS to this antibiotic. Even though fewer than 5 % of GAS isolates are reported as resistant to macrolide, lincosamide, and streptogramin (MLS) antibiotics (2,6), local exceptions have been reported, and widespread GAS resistance to erythromycin has so far been
Keyphrases
dispatch rapid increase streptococcus pyogenes life-threatening infection several part enhanced awareness normal level marked variation local exception past year 20-fold increase erythromycin resistance sharp increase increased clinical use upper respiratory tract infection erythromycinresistant strain medical community increased frequency gas isolates antibiotic resistance severe infection geographic area mean value widespread gas resistance group streptococcus gas
