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Microarrays, Empirical Bayes Methods, and False Discovery Rates (2001)
| Venue: | Genet. Epidemiol |
| Citations: | 216 - 14 self |
BibTeX
@ARTICLE{Efron01microarrays,empirical,
author = {Bradley Efron and John D. Storey and Robert Tibshirani},
title = {Microarrays, Empirical Bayes Methods, and False Discovery Rates},
journal = {Genet. Epidemiol},
year = {2001},
volume = {23},
pages = {70--86}
}
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Abstract
In a classic two-sample problem one might use Wilcoxon's statistic to test for a dierence between Treatment and Control subjects. The analogous microarray experiment yields thousands of Wilcoxon statistics, one for each gene on the array, and confronts the statistician with a dicult simultaneous inference situation. We will discuss two inferential approaches to this problem: an empirical Bayes method that requires very little a priori Bayesian modeling, and the frequentist method of \False Discovery Rates" proposed by Benjamini and Hochberg in 1995. It turns out that the two methods are closely related and can be used together to produce sensible simultaneous inferences.
