DMCA
Complete Genome Sequence of the Prototype Lactic Acid Bacterium (2006)
| Citations: | 45 - 6 self |
BibTeX
@MISC{Wegmann06completegenome,
author = {Udo Wegmann and Aldert Zomer and Girbe Buist and Claire Shearman and Carlos Canchaya and Marco Ventura and Er Goesmann and Michael J. Gasson and Oscar P. Kuipers and Douwe Van Sinderen and Jan Kok},
title = {Complete Genome Sequence of the Prototype Lactic Acid Bacterium},
year = {2006}
}
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Abstract
Lactococcus lactis is of great importance for the nutrition of hundreds of millions of people worldwide. This paper describes the genome sequence of Lactococcus lactis subsp. cremoris MG1363, the lactococcal strain most intensively studied throughout the world. The 2,529,478-bp genome contains 81 pseudogenes and encodes 2,436 proteins. Of the 530 unique proteins, 47 belong to the COG (clusters of orthologous groups) functional category “carbohydrate metabolism and transport, ” by far the largest category of novel proteins in comparison with L. lactis subsp. lactis IL1403. Nearly one-fifth of the 71 insertion elements are concentrated in a specific 56-kb region. This integration hot-spot region carries genes that are typically associated with lactococcal plasmids and a repeat sequence specifically found on plasmids and in the “lateral gene transfer hot spot ” in the genome of Streptococcus thermophilus. Although the parent of L. lactis MG1363 was used to demonstrate lysogeny in Lactococcus, L. lactis MG1363 carries four remnant/satellite phages and two apparently complete prophages. The availability of the L. lactis MG1363 genome sequence will reinforce its status as the prototype among lactic acid bacteria through facilitation of further applied and fundamental research. Lactococcus lactis, a mesophilic fermentative bacterium producing lactic acid from sugar (hexose) fermentation, is an important
Keyphrases
complete genome sequence prototype lactic acid bacterium lactococcus lactis lactis mg1363 specific 56-kb region lactococcal plasmid orthologous group lactic acid bacteria great importance fundamental research genome sequence lactis mg1363 genome sequence streptococcus thermophilus lactis il1403 insertion element integration hot-spot region lactococcal strain cremoris mg1363 functional category carbohydrate metabolism novel protein lactic acid mesophilic fermentative bacterium lactococcus lactis subsp lateral gene transfer hot spot lactis subsp 478-bp genome complete prophages remnant satellite phage unique protein repeat sequence
