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Flow-injection chemiluminescent determination of cefprozil using Tris (2,20-bipyridyl) ruthenium (II)-permanganate system (2006)
| Venue: | Journal of Pharmaceutical and Biomedical Analysis |
| Citations: | 1 - 0 self |
BibTeX
@ARTICLE{Alarfaj06flow-injectionchemiluminescent,
author = {Nawal A Alarfaj and Sawsan A Abd El-Razeq},
title = {Flow-injection chemiluminescent determination of cefprozil using Tris (2,20-bipyridyl) ruthenium (II)-permanganate system},
journal = {Journal of Pharmaceutical and Biomedical Analysis},
year = {2006},
pages = {1423--1427}
}
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Abstract
Abstract A rapid and sensitive chemiluminescence (CL) method using flow-injection (FI) has been developed for the determination of a second generation cephalosporin, cefprozil. The method is based on the CL reaction of cefprozil with acidic potassium permanganate and tris (2,2 -bipyridyl) ruthenium (II), Ru (bipy) 3 2+ . The CL intensity is greatly enhanced when quinine sulfate is used as a sensitizer. After optimization of the different experimental parameters, a calibration graph was obtained over a concentration range of 0.1-3.0 g ml −1 with minimum detectability of 0.005 g ml −1 (S/N = 3). The correlation coefficient was 0.9998 (n = 6) with a relative standard deviation (%R.S.D.) of 1.63% for 2.0 g ml −1 . The proposed method was successfully applied to commercial tablets. The average percentage recovery (n = 6) was 99.9 ± 1.40.
