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Computational methods in noncoding RNA research (2008)
| Venue: | J. MATH. BIOL. (2008) 56:15–49 |
| Citations: | 14 - 1 self |
BibTeX
@MISC{Machado-lima08computationalmethods,
author = {Ariane Machado-lima and Hernando A. Del Portillo and Alan Mitchell Durham},
title = { Computational methods in noncoding RNA research},
year = {2008}
}
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Abstract
Non protein-coding RNAs (ncRNAs) are a research hotspot in bioinfor-matics. Recent discoveries have revealed new ncRNA ... families performing a variety of roles, from gene expression regulation to catalytic activities. It is also believed that other families are still to be unveiled. Computational methods developed for protein coding genes often fail when searching for ncRNAs. Noncoding RNAs functionality is often heavily dependent on their secondary structure, which makes gene discovery very different from protein coding RNA genes. This motivated the development of specific methods for ncRNA research. This article reviews the main approaches used to identify ncRNAs and predict secondary structure.
Keyphrases
s00285-007-0122-6 mathematical biology computational method rna research recent discovery secondary structure ncrna research catalytic activity abstract non protein-coding rna gene expression regulation main approach specific method predict secondary structure new ncrna family noncoding rna functionality research hotspot rna gene computational method
