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Editorial Response: The Need for Investigations of Prophylactic Regimens to Prevent AIDS-Associated Non-Hodgkin's Lymphoma (2000)
BibTeX
@MISC{Rabkin00editorialresponse:,
author = {Charles S. Rabkin and From Viral and Epidemiology Branch},
title = {Editorial Response: The Need for Investigations of Prophylactic Regimens to Prevent AIDS-Associated Non-Hodgkin's Lymphoma},
year = {2000}
}
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Abstract
Combination antiretroviral therapy is now standard care and received by the majority of HIV-infected patients in this country [1]. Although HIV-infected patients are surviving longer, the long-term consequences of prolonged survival under such ther-apy remain unde®ned. Alteration of cancer risk is of particular concern, and HIV-associated cancers have already emerged as a leading cause of death among patients with AIDS [2]. In particular, HIV infection is associated with increased in-cidence of non-Hodgkin's lymphoma (NHL), exceeding 1 % an-nually in recent data [1, 3]. NHL incidence increases markedly with progression of HIV infection, although the association with level of CD4 lymphopenia is less pronounced than that for many other opportunistic infections [4, 5]. Among the AIDS-de®ning opportunistic illnesses, NHL has accounted for 3 % of clinical AIDS cases in the United States [6].
