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Actin depolymerization transduces the strength of B-cell receptor stimulation (2005)
| Venue: | Mol. Biol. Cell |
| Citations: | 23 - 0 self |
BibTeX
@ARTICLE{Hao05actindepolymerization,
author = {Shengli Hao and Avery August},
title = {Actin depolymerization transduces the strength of B-cell receptor stimulation},
journal = {Mol. Biol. Cell},
year = {2005},
pages = {16--2275}
}
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Abstract
Polymerization of the actin cytoskeleton has been found to be essential for B-cell activation. We show here, however, that stimulation of BCR induces a rapid global actin depolymerization in a BCR signal strength-dependent manner, followed by polarized actin repolymerization. Depolymerization of actin enhances and blocking actin depolymerization inhibits BCR signaling, leading to altered BCR and lipid raft clustering, ERK activation, and transcription factor activation. Furthermore actin depolymerization by itself induces altered lipid raft clustering and ERK activation, suggesting that F-actin may play a role in separating lipid rafts and in setting the threshold for cellular activation.
Keyphrases
actin depolymerization b-cell receptor stimulation lipid raft clustering erk activation actin depolymerization inhibits bcr signaling bcr signal strength-dependent manner polarized actin repolymerization furthermore actin depolymerization b-cell activation cellular activation lipid raft actin enhances transcription factor activation rapid global actin depolymerization actin cytoskeleton
