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...xpression of p27, a gene encoding cyclindependent kinase inhibitor 1B, was indicated to be significantly reduced in NPC tissues and cells, hinting its potentially suppressive role in NPC pathogenesis =-=[6]-=- (Additional file 1: Figure S1). P27 is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhi...

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...been reported in several references [13,14].p27 was found the low expression level may contribute to the aggressive behavior of NPC byCAACGCTTTTAGAGGCAGAT-3′. ARF gene was used as an internal control =-=[3]-=-.Age(y) ≥50 62 30 32 <50 68 32 36 1.000 Smoking Yes 32 21 11 No 98 41 57 0.025 Recurrence Yes 4 2 2Table 1 Correlation between the clinicopathologic characteristics and expression of p27 protein in NP...

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...tive expression of p27 in NPC tissues.(insetsmost common in nasopharyngeal region. It is a disease with disorder of cell cycle and uncontrolled growth due to abnormal expression of cell cycle factors =-=[4,6,16]-=-. P27, a key cell cycle protein kinase inhibitor, formed a complex with CCND1 and CDK4 that prevents CDK4 from adding phosphate residues to its principal substrate, the retinoblastoma (pRb) protein an...

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...in was not an independent predictor of prognosis for NPC patients regardless of its patients’ disease status. This result was not consistent with the reports from other tumors including breast cancer =-=[22]-=- and glioma [23] etc. In summary, our results provide evidence that expression of p27 may be involved in the clinical progression and poor prognosis of NPC patients. However, it could not serve as a p...

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...cinoma derived from mucosal epithelium of the naso- genes among NPC and nasopharyngeal tissues (NP) and Jiang et al. Diagnostic Pathology 2013, 8:212 http://www.diagnosticpathology.org/content/8/1/212=-=[8]-=-, gastric cancer [9], colorectal cancer [10] et al., whichGuangzhou 510000, PR ChinaFull list of author information is available at the end of the articlepharynx correlated with EBV infection, environ...

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... as Cyclin A/Cdk2 and Cyclin E/Cdk2 and suppress the transition of cell cycle. Decreased expression of p27 has been indicated in many tumors, including lung cancer [17], bladder cancer [18], melanoma =-=[19]-=-, and ovarian cancer [20], prostate cancer [21], which was associated with the unfavorable clinical parameters and poor outcomes of these tumors. However, the role of p27 is still unclear in NPC. Tabl...

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...hich belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. In previous investigations, downexpression of P27 had been indicated in many tumor types, including lung cancer =-=[7]-=-, hepatocellular carcinoma * Correspondence: 29606771@qq.com; 7102981@qq.com †Equal contributors 3Cancer Research Institute, Southern Medical University, Guangzhou 510515, PR China 2Department of Path...

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...hogenesis [11,12]. Based on the above reports mentioned, p27 was taken as an important gene participating in tumor pathogenesis. The role p27 plays in NPC has also been reported in several references =-=[13,14]-=-.p27 was found the low expression level may contribute to the aggressive behavior of NPC byCAACGCTTTTAGAGGCAGAT-3′. ARF gene was used as an internal control [3].Age(y) ≥50 62 30 32 <50 68 32 36 1.000 ...

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...with EBV infection, environmental factors and genetic aberrance. Among them, EBV infection is the most important for NPC, when other cancers in upper digestive tract have something with to do with it =-=[1]-=-. The initiation and progression of NPC is a complex and consecutive process with the participation of observed that expression of p27, a gene encoding cyclindependent kinase inhibitor 1B, was indicat...

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...ochemistry Immunohistochemistry was utilized to examine the protein expression of p27 with rabbit anti-human p27 antibody (1:100) (Santa Cruz Biotechnology, USA) according to the previous description =-=[2]-=-. Sections were visualized with DAB and counterstained with hematoxylin, mounted in neutral gum, and analyzed using a bright field microscope. Evaluation of staining The immunohistochemically stained ...

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...it connected to cyclin subunits such as Cyclin A/Cdk2 and Cyclin E/Cdk2 and suppress the transition of cell cycle. Decreased expression of p27 has been indicated in many tumors, including lung cancer =-=[17]-=-, bladder cancer [18], melanoma [19], and ovarian cancer [20], prostate cancer [21], which was associated with the unfavorable clinical parameters and poor outcomes of these tumors. However, the role ...

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...n subunits such as Cyclin A/Cdk2 and Cyclin E/Cdk2 and suppress the transition of cell cycle. Decreased expression of p27 has been indicated in many tumors, including lung cancer [17], bladder cancer =-=[18]-=-, melanoma [19], and ovarian cancer [20], prostate cancer [21], which was associated with the unfavorable clinical parameters and poor outcomes of these tumors. However, the role of p27 is still uncle...

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...lin E/Cdk2 and suppress the transition of cell cycle. Decreased expression of p27 has been indicated in many tumors, including lung cancer [17], bladder cancer [18], melanoma [19], and ovarian cancer =-=[20]-=-, prostate cancer [21], which was associated with the unfavorable clinical parameters and poor outcomes of these tumors. However, the role of p27 is still unclear in NPC. Table 2 Protein expression of...

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...s the transition of cell cycle. Decreased expression of p27 has been indicated in many tumors, including lung cancer [17], bladder cancer [18], melanoma [19], and ovarian cancer [20], prostate cancer =-=[21]-=-, which was associated with the unfavorable clinical parameters and poor outcomes of these tumors. However, the role of p27 is still unclear in NPC. Table 2 Protein expression of p27 between NPC and N...

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...dependent predictor of prognosis for NPC patients regardless of its patients’ disease status. This result was not consistent with the reports from other tumors including breast cancer [22] and glioma =-=[23]-=- etc. In summary, our results provide evidence that expression of p27 may be involved in the clinical progression and poor prognosis of NPC patients. However, it could not serve as a potential indepen...

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...rous fresh nasopharyngeal samples were collected atinduced the progression and poor prognosis of these tumors. Further, p27 was observed to act as a significant role in suppressing tumor pathogenesis =-=[11,12]-=-. Based on the above reports mentioned, p27 was taken as an important gene participating in tumor pathogenesis. The role p27 plays in NPC has also been reported in several references [13,14].p27 was f...

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...ewed and scored separately by two pathologists blinded to the clinical parameters. Expression of p27 in the nucleus and in the cytoplasm was independently evaluated and scored as previously described =-=[12]-=-. The sum of the cytoplasm and Female 37 13 24 0.082 No 126 60 66 1.000 T classification T1-T2 90 51 39 T3-T4 40 11 29 0.002 N classification N0-N1 73 38 35 N2-N3 57 24 33 0.291 Distant metastasis Yes...

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...hogenesis [11,12]. Based on the above reports mentioned, p27 was taken as an important gene participating in tumor pathogenesis. The role p27 plays in NPC has also been reported in several references =-=[13,14]-=-.p27 was found the low expression level may contribute to the aggressive behavior of NPC byCAACGCTTTTAGAGGCAGAT-3′. ARF gene was used as an internal control [3].Age(y) ≥50 62 30 32 <50 68 32 36 1.000 ...