Leishmania-Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite

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Leishmania-Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite

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by Metalloprotease Gp , Irazú Contreras , María Adelaida Gómez , Oliver Nguyen , Marina T. Shio , Robert W. Mcmaster , Martin Olivier

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270	Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis, - DESJEUX - 2004 (Show Context) Citation Context ...martin.olivier@mcgill.ca Introduction Parasites of the Leishmania genus are the causative agent of leishmaniasis; a disease distributed worldwide affecting more than 12 million people in 88 countries =-=[1]-=-. Leishmaniasis is a complex of diseases ranging from self-healing cutaneous lesions to lethal visceral afflictions [2]. In its mammalian host, Leishmania is an obligate intracellular pathogen infecti...
39	AP-1: One switch for Many signals - Wisdom - 1999 (Show Context) Citation Context ...ates gene regulation in response to physiological and pathological stimuli, including cytokines, growth factors, stress signals, bacterial and viral infections, apoptosis, as well oncogenic responses =-=[6,7]-=-. AP-1 is formed by homodimers of Jun family members (c-Jun, Jun B and Jun D), or heterodimers of Jun and Fos family members (cFos, Fos B, Fra 1 and Fra 2). Homodimers within the Fos family do not occ...
33	Schorpp-Kistner M (2004) AP-1 subunits: quarrel and harmony among siblings - Hess, Angel
28	Activation of phosphotyrosine phosphatase activity attenuates mitogen- activated protein kinase signaling and inhibits c-FOS and nitric oxide synthase expression in macrophages infected with Leishmania donovani. I n f e c t Immun 6 7 - Nandan, Lo, et al. - 1999 (Show Context) Citation Context ...10]. Other studies have shown that Leishmania alters signal transduction upstream of c-Fos and c-Jun by inhibiting ERK, JNK and p38 MAP Kinases, resulting in a reduction of AP-1 nuclear translocation =-=[11,12]-=-. However, little is known about the molecular mechanism (s) by which Leishmania parasites are able to inactivate this important transcription factor. Many Leishmania-specific factors such as lipophos...
27	Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1/2 during infection of naive macrophages - Prive, Descoteaux (Show Context) Citation Context ...10]. Other studies have shown that Leishmania alters signal transduction upstream of c-Fos and c-Jun by inhibiting ERK, JNK and p38 MAP Kinases, resulting in a reduction of AP-1 nuclear translocation =-=[11,12]-=-. However, little is known about the molecular mechanism (s) by which Leishmania parasites are able to inactivate this important transcription factor. Many Leishmania-specific factors such as lipophos...
27	Loss of virulence in Leishmania donovani deficient in an amastigote-specific protein, A2. - Zhang, Matlashewski - 1997 (Show Context) Citation Context ...n its mammalian host cells. Better knowledge concerning the mechanisms whereby this pathogen can escape the innate immune response may help to develop new anti-Leishmania therapy. amastigote survival =-=[14]-=-.The cysteine peptidases of L. mexicana are implicated in facilitating the survival and growth of the parasite [15]. Furthermore GP63, also known as the major surface protease (MSP), has been related ...
23	Leishmania donovani suppresses activated protein 1 and NF-κB activation in host macrophages via ceramide generation: involvement of extracellular signal-regulated kinase,” - Ghosh, Bhattacharyya, et al. - 2002 (Show Context) Citation Context ... concentration, which leads to the down-regulation of classical PKC activity, up-regulation of calcium independent atypical PKC-f and dephosphorylation of Extracellular Signal-Regulated Kinases (ERK) =-=[9,10]-=-. Other studies have shown that Leishmania alters signal transduction upstream of c-Fos and c-Jun by inhibiting ERK, JNK and p38 MAP Kinases, resulting in a reduction of AP-1 nuclear translocation [11...
20	DJ, Forget G (2005) Subversion Mechanisms by Which Leishmania Parasites Can Escape the Host Immune Response: a Signaling Point of View. Clin Microbiol Rev 18: 293–305 - Olivier, Gregory (Show Context) Citation Context ...hese cells, Leishmania has evolved sophisticated mechanisms to subvert macrophage microbicidal functions such as inhibition of nitric oxide (NO) production and cytokine-inducible macrophage functions =-=[3]-=-. This occurs as the direct consequence of parasite-mediated activation of protein tyrosine phosphatases, alteration of signal transduction and inhibition of nuclear translocation and activity of tran...
14	E-G and Zandi E - Karin, Liu - 1997 (Show Context) Citation Context ...un family members (c-Jun, Jun B and Jun D), or heterodimers of Jun and Fos family members (cFos, Fos B, Fra 1 and Fra 2). Homodimers within the Fos family do not occur due to conformational repulsion =-=[8]-=-. Previous studies have reported that the AP-1 transcription factor is inactivated by Leishmania infection. For instance, activation of macrophage AP-1 and NF-kB is inhibited by L. donovani promastigo...
12	Cysteine peptidases as virulence factors of Leishmania. Curr Opin Microbiol 7: 375–381 - JC, GH, et al. - 2004 (Show Context) Citation Context ...immune response may help to develop new anti-Leishmania therapy. amastigote survival [14].The cysteine peptidases of L. mexicana are implicated in facilitating the survival and growth of the parasite =-=[15]-=-. Furthermore GP63, also known as the major surface protease (MSP), has been related to resistance to complement-mediated lysis, among others [16,17]. GP63 is a metalloprotease which belongs to the me...
8	Glycoconjugates in Leishmania infectivity. Biochimica et biophysica acta - Descoteaux, SJ - 1999 (Show Context) Citation Context ..., A2 proteins, cysteine peptidases (CPs) and the protease GP63, contribute to Leishmania virulence and pathogenicity. LPG has been implicated in altering phagosome maturation in L. donovani infection =-=[13]-=-.The A2 proteins of L. donovani are involved in intracellular PLoS Pathogens \| www.plospathogens.org 1 October 2010 \| Volume 6 \| Issue 10 \| e1001148AP-1 Inactivation by Leishmania Protease GP63 Autho...
6	M (2005) Proteasome-mediated Degradation of STAT1alpha following Infection of Macrophages with Leishmania donovani - Forget, DJ, et al. (Show Context) Citation Context ...mediated activation of protein tyrosine phosphatases, alteration of signal transduction and inhibition of nuclear translocation and activity of transcription factors such as NF-kB, STAT, CREB and AP-1=-=[4,5]-=-. Activated Protein-1 (AP-1) is an important transcription factor that mediates gene regulation in response to physiological and pathological stimuli, including cytokines, growth factors, stress signa...
3	Mallia AC (2006) Leishmaniasis - TV (Show Context) Citation Context ...ease distributed worldwide affecting more than 12 million people in 88 countries [1]. Leishmaniasis is a complex of diseases ranging from self-healing cutaneous lesions to lethal visceral afflictions =-=[2]-=-. In its mammalian host, Leishmania is an obligate intracellular pathogen infecting hematopoietic cells of the monocyte/macrophage lineage. Macrophages are specialized for the destruction of invading ...
3	Raha S, Maulik N, et al. (2001) Generation of ceramide in murine macrophages infected with Leishmania donovani alters macrophage signaling events and aids intracellular parasitic survival. Mol Cell Biochem 223 - Ghosh, Bhattacharyya, et al. (Show Context) Citation Context ... concentration, which leads to the down-regulation of classical PKC activity, up-regulation of calcium independent atypical PKC-f and dephosphorylation of Extracellular Signal-Regulated Kinases (ERK) =-=[9,10]-=-. Other studies have shown that Leishmania alters signal transduction upstream of c-Fos and c-Jun by inhibiting ERK, JNK and p38 MAP Kinases, resulting in a reduction of AP-1 nuclear translocation [11...
2	M (2008) A novel form of NF-kB is induced by Leishmania infection: Involvement in macrophage gene expression - DJ, Godbout, et al. (Show Context) Citation Context ...mediated activation of protein tyrosine phosphatases, alteration of signal transduction and inhibition of nuclear translocation and activity of transcription factors such as NF-kB, STAT, CREB and AP-1=-=[4,5]-=-. Activated Protein-1 (AP-1) is an important transcription factor that mediates gene regulation in response to physiological and pathological stimuli, including cytokines, growth factors, stress signa...