CD163 and its role in inflammation

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CD163 and its role in inflammation

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by Internal Medicine , Krzysztof Kowal , Richard Silver , Emila Sławińska , Marek Bielecki , Lech Chyczewski Otylia

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62	Sieweke MH, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science - Geissmann, MG, et al. (Show Context) Citation Context ...istochemica et Cytobiologica 2011, Vol. 49, No. 3, 365–374) Key words: CD163, inflammation Introduction Monocytes and macrophages play an important role in the regulation of the inflammatory response =-=[1, 2]-=-. Based on their functional properties, at least two subpopulations (M1 and M2) of mononuclear phagocytes, which differ in their pro- and anti-inflammatory potential, have been described [3]. The cell...
55	Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli,” - Buechler, Ritter, et al. - 2000 (Show Context) Citation Context ...re divided according to their expression of the endotoxin receptor (CD14) and the high affinity immunoglobulin G receptor type III (FcgRIII — CD16), four different subpopulations can be distinguished =-=[18, 19]-=-. The highest expression of CD163 is found on CD14highCD16+ and the lowest on CD14lowCD16– cells [18, 19]. Cells in the CD14highCD16+ subpopulation have been reported to exert predominantly anti-infla...
37	Sorg C. Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteines-rich family (CD163 - Hogger, Dreier, et al. - 1998 (Show Context) Citation Context ...h differentiation of such cells into macrophages [14–17]. Original reports using Ber-Mac3 or RM3/1 antibodies demonstrated expression of CD163 on 5% or 30% of freshly isolated monocytes, respectively =-=[14, 15]-=-. More recent reports, however, have demonstrated CD163 expression on a majority of peripheral blood monocytes [16, 17]. The discrepancies in reported expression of CD163 on freshly isolated periphera...
31	Taams LS. CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. - MM, AL, et al. - 2007 (Show Context) Citation Context ... induced by CD4+CD25+Foxp3+ T regulatory cells and for rebound up-regulation of monocyte/macrophage CD163 expression after shedding of the receptor in response to Toll like receptor (TLR) stimulation =-=[27, 28]-=-. Glucocorticoids are at least equally potent inducers of CD163 expression [16, 26]. The magnitude of up-regulation of CD163 expression depends on the potency of the glucocorticoid: those having the g...
24	Monocytes: subsets, origins, fates and functions. - Yona, Jung - 2010 (Show Context) Citation Context ...sponse [1, 2]. Based on their functional properties, at least two subpopulations (M1 and M2) of mononuclear phagocytes, which differ in their pro- and anti-inflammatory potential, have been described =-=[3]-=-. The cells of the M1 subpopulation secrete predominantly pro-inflammatory mediators which trigger and amplify inflammatory responses. Those of the M2 subpopulation produce mainly anti-inflammatory me...
22	Graversen JH, Jacobsen C et al. Identification of the haemoglobin scavenger receptor. Nature. 2001;409 - Kristiansen (Show Context) Citation Context ... CD163 binds to hemoglobin-haptoglobin (Hb-Hp) complexes, resulting in internalization of the complexes and preventing oxidative stress and inflammation associated with extracellular metabolism of Hb =-=[50]-=-. Using a ligand-affinity approach, CD163 was shown to be a specific receptor for Hb-Hp complexes, but not for Hb or Hp alone [50]. When released from erythrocytes, Hb binds to Hp to form complexes co...
19	IL-10 expressing profiling in human monocytes - Williams, Jarai, et al. (Show Context) Citation Context ...ucocorticoids and interleukin-10 (IL-10) [16, 18, 23–26]. In fact, in experiments utilizing gene-chip technology, CD163 displays the strongest response to IL-10 among all 19 of the up-regulated genes =-=[25]-=-. Interleukin 10 is also responsible for up-regulation of monocyte/macrophage CD163 expression induced by CD4+CD25+Foxp3+ T regulatory cells and for rebound up-regulation of monocyte/macrophage CD163 ...
17	Soluble CD163 inhibits phorbol ester-induced lymphocyte proliferation. Biochem Biophys Res Commun - Hogger, Sorg (Show Context) Citation Context ...ot only does cell surface CD163 play a role in the modulation of the inflammatory response, soluble CD163 (sCD163) also can actively regulate that process. Soluble CD163 inhibits T cell proliferation =-=[63, 64]-=-. Purified sCD163 inhibited in a dose-dependent manner phorbol ester-induced T cell proliferation in vitro, at an optimal concentration of sCD163 of 0.5 mcg/ml [63, 64]. This anti-proliferatory functi...
16	Ber-MAC3: new monoclonal antibody that defines human monocyte/macrophage differentiation antigen.J - Backe, Schwarting, et al. - 1991 (Show Context) Citation Context ...h differentiation of such cells into macrophages [14–17]. Original reports using Ber-Mac3 or RM3/1 antibodies demonstrated expression of CD163 on 5% or 30% of freshly isolated monocytes, respectively =-=[14, 15]-=-. More recent reports, however, have demonstrated CD163 expression on a majority of peripheral blood monocytes [16, 17]. The discrepancies in reported expression of CD163 on freshly isolated periphera...
14	Breedam W, Delputte PL, Nauwynck HJ. Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus - Gorp, van (Show Context) Citation Context ...wever, CD163, in contrast to TLRs, can recognize and bind intact bacteria and not only soluble microbial components [56]. In pigs, an important role of CD163 in viral infections has been demonstrated =-=[57, 58]-=-. Two viruses, African swine fever virus (ASFV) and porcine reproductive and respiratory syndrome virus (PRRSV), use CD163 as an entry into the target cells of pigs [57, 58]. The ASFV uses CD163 as a ...
12	Vogel SN, Guyre PM. Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptors - LK, PA, et al. (Show Context) Citation Context ... induced by CD4+CD25+Foxp3+ T regulatory cells and for rebound up-regulation of monocyte/macrophage CD163 expression after shedding of the receptor in response to Toll like receptor (TLR) stimulation =-=[27, 28]-=-. Glucocorticoids are at least equally potent inducers of CD163 expression [16, 26]. The magnitude of up-regulation of CD163 expression depends on the potency of the glucocorticoid: those having the g...
12	BJ et al. Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: anti-inflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery. Circ Res - Philipidis, JC, et al. (Show Context) Citation Context ...CD163. One of the anti-CD163 antibodies, Ki-m8, possesses agonistic properties, and it has been shown that application of this antibody leads to induction of IL-10 secretion by mononuclear phagocytes =-=[49]-=-. In 2001, Kristiansen et al. demonstrated that CD163 binds to hemoglobin-haptoglobin (Hb-Hp) complexes, resulting in internalization of the complexes and preventing oxidative stress and inflammation ...
12	Zheng TS. TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease. Cytokine - LC, JS, et al. (Show Context) Citation Context ...3 [54]. TWEAK is a member of the TNF superfamily and plays many important roles in the processes associated with tissue damage and repair, e.g. inflammation, proliferation, apoptosis and angiogenesis =-=[59]-=-. Its ability to regulate innate and adaptive immune response seems to be one of the most interesting aspects of TWEAK from an immunological point of view [60]. In mice with genetically silenced TWEAK...
11	The scavenger receptor CD163: regulation, promoter structure and genomic organization. Pathobiology - Ritter, Buechler, et al. - 1999
10	Oxidative stress and 8-iso-prostaglandin F2a induce ectodomain shedding of CD163 and release of tumor necrosis factor-a from human monocytes. Free Radic Biol Med - Timmermann, Hogger (Show Context) Citation Context ...been shown to involve a metalloproteinase-dependent process [29, 32]. The same mechanism is responsible for down-regulation of monocyte CD163 expression by oxidative stress or 8-iso-prostaglandin F2a =-=[33]-=-. Prolonged stimulation with cell membrane TLR agonists, however, leads to a rebound up-regulation of CD163 to levels higher than those observed before stimulation with TLR ligands [28]. This effect d...
10	Only soluble form of the scavenger receptor CD163 acts inhibitory on phorbol ester-activated T-lymphocytes, whereas membrane-bound protein has no effect. FEBS Letters - Frings, Dreier, et al. (Show Context) Citation Context ...ot only does cell surface CD163 play a role in the modulation of the inflammatory response, soluble CD163 (sCD163) also can actively regulate that process. Soluble CD163 inhibits T cell proliferation =-=[63, 64]-=-. Purified sCD163 inhibited in a dose-dependent manner phorbol ester-induced T cell proliferation in vitro, at an optimal concentration of sCD163 of 0.5 mcg/ml [63, 64]. This anti-proliferatory functi...
9	Phenotypic dynamics of macrophage subpopulations during experimental gingivitis. J Peridont Res - HH, Zwadlo, et al. - 1989 (Show Context) Citation Context ...alveolar macrophages [12, 20]. The level of expression of CD163 on tissue macrophages has been shown to increase during the resolution of acute inflammatory response or during the wound healing phase =-=[21, 22]-=-. Neither granulocytes nor dendritic cells express significant levels of CD163. Expression of CD163 also depends on the maturation stage of monocytes/macrophages. To date, only one monocytic cell line...
8	Lenczewska D, Dabrowska M. Enhanced frequencies of CD14++CD16+, but not CD14+CD16+, peripheral blood monocytes in severe asthmatic patients. Clin Immunol - Moniuszko, Bodzenta-Lukaszyk, et al. (Show Context) Citation Context ...re divided according to their expression of the endotoxin receptor (CD14) and the high affinity immunoglobulin G receptor type III (FcgRIII — CD16), four different subpopulations can be distinguished =-=[18, 19]-=-. The highest expression of CD163 is found on CD14highCD16+ and the lowest on CD14lowCD16– cells [18, 19]. Cells in the CD14highCD16+ subpopulation have been reported to exert predominantly anti-infla...
8	Boretti FS, Schoedon G, Schaffner A. Induction of the CD163-dependent haemoglobin uptake by macrophages as a novel antiinflammatory action of glucocorticoids - DJ
7	Delputte PL, Nauwynck HJ. Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell directed therapy. Mol Immunol. 2010; epub - Gorp (Show Context) Citation Context ...les have been used to identify those subpopulations. Recently, CD163 has been proposed to be a specific marker of monocytes/macrophages cell populations exhibiting strong anti-inflammatory properties =-=[4]-=-. Although CD163 is a marker of anti-inflammatory monocytes/macrophages, it also transduces signals upon binding of its ligands that lead to release of anti-inflammatory mediators such as interleukin-...
7	Graversen JH, Moestrup SK. Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma - HJ, NA (Show Context) Citation Context ...protein CD163 gene expression is tightly regulated in both a tissue-specific and a differentiation-specific manner [8, 12]. It is detectable as both a cell surface receptor and also as a soluble form =-=[13]-=-. Cellular expression of CD163 is restricted to monocytes and macrophages [8, 12]. Freshly isolated peripheral blood monocytes express a relatively low level of CD163, but this expression increases wi...
7	AE et al. Human monocytes express CD163, which is upregulated by IL-10 and identical to p155. Cytokine - TH, Hogger, et al. (Show Context) Citation Context ...ted expression of CD163 on 5% or 30% of freshly isolated monocytes, respectively [14, 15]. More recent reports, however, have demonstrated CD163 expression on a majority of peripheral blood monocytes =-=[16, 17]-=-. The discrepancies in reported expression of CD163 on freshly isolated peripheral blood monocytes may be explained by the application of different antibodies and by different techniques used for mono...
7	Heuvel MM, Tensen CP, van As JH et al. Regulation of CD163 on human macrophages: cross-linking of CD163 induces signaling and activation - den - 1999 (Show Context) Citation Context ...ophages, with the exception of lymphoid follicle macrophages, express CD163 on their surfaces and the expression is particularly high on liver Kupffer cells and on peritoneal and alveolar macrophages =-=[12, 20]-=-. The level of expression of CD163 on tissue macrophages has been shown to increase during the resolution of acute inflammatory response or during the wound healing phase [21, 22]. Neither granulocyte...
7	C et al. Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene - MC, Puppo, et al. (Show Context) Citation Context ...nists [28]. Activation of intracellular TLRs does not, however, affect CD163 expression. Other factors which down-regulate CD163 expression include hypoxia and crosslinking of Fcgamma receptor (FcgR) =-=[34, 35]-=-. Hypoxia leads to inhibition of CD163 at the transcriptional level, while cross-linking of FcgR results in shedding of CD163 from the cell surface [34, 35]. Immunoglobulin G immobilized on a culture ...
7	Goulding NJ. Macrophage subpopulations in rheumatoid synovium. Reduced CD163 expression in CD4+ T lymphocyte-rich microenvironments. Arthritis Rheum - JE, JCW, et al. (Show Context) Citation Context ... [65]. The associations between T cell proliferation and CD163 also come from in vivo studies in which elevated tissue expression of sCD163 is found in places where T cell proliferation is attenuated =-=[66]-=-. In par372 K Kowal et al. ©Polish Society for Histochemistry and Cytochemistry Folia Histochem Cytobiol. 2011 10.5603/FHC.2011.0052 www.fhc.viamedica.pl ticular, in patients with rheumatoid arthritis...
6	Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor 373CD163 in inflammation ©Polish Society for Histochemistry and Cytochemistry Folia Histochem Cytobiol - Ritter, Buechler, et al. (Show Context) Citation Context ...ovial fluids [4]. It contains most of the extracellular part of the membrane CD163, including all SRCR domains [4]. Gene structure The CD163 gene is located on the short arm of chromosome 12 (p13.31) =-=[7]-=-. A gene encoding CD163 molecule-like 1 is also located in the same region close to CD163. The CD163 molecule-like 1 (CD163-L1) gene is highly homologous to the CD163 gene and has the same orientation...
6	JM et al. A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. Eur J Immunol - SKA, KJ, et al. - 1993 (Show Context) Citation Context ...ent 1s and 1r, tumor necrosis factor receptor-1, lymphotoxin-beta receptor, alpha2-macroglobulin, CD9, CD27, and CD69 [7]. The CD163 gene spans more than 35 kb and consists of 17 exons and 16 introns =-=[7, 8]-=- (Figure 1). The first ATG codon is located in exon 1, and that exon also contains the N-terminal part of the signal peptide. The remaining parts of the signal peptide are encoded by exon 2 and the fi...
6	Boretti FS, Hongegger A et al. Molecular cloning and characterization of the mouse CD163 homologue, a highly glucocorticoid-inducible member of the scavenger receptor cysteines-rich family. Immunogenetics - DJ (Show Context) Citation Context ...d some of them may encode truncated CD163 protein [7, 8]. No functional role for these individual CD163 splice variants has yet been described [7, 8]. Murine CD163 is highly homologous to human CD163 =-=[10]-=-. The gene encoding mouse CD163 is located on chromosome 6 in close proximity to complement components 1r and 1s and to CD9 [11]. That location is homologous to the gene cluster on human chromosome 12...
6	Parwaresch MR. Ki-M8 monoclonal antibody reactive with and intracytoplasmic antigen of monocyte/macrophage lineage - HJ, Kriepe, et al. - 1987 (Show Context) Citation Context ...lso seen among swine, rat, monkey and human CD163 receptors [4]. Expression of CD163 protein CD163 gene expression is tightly regulated in both a tissue-specific and a differentiation-specific manner =-=[8, 12]-=-. It is detectable as both a cell surface receptor and also as a soluble form [13]. Cellular expression of CD163 is restricted to monocytes and macrophages [8, 12]. Freshly isolated peripheral blood m...
6	Shaked I, Erbel C, Bockler D, Katus HA, Ley K. CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages. Circ Res - CA (Show Context) Citation Context ...hages, but also dampen IL-10- or glucocorticoid-induced CD163 expression [16]. Surprisingly, transforming growth factor-beta (TGF-b), which is an anti-inflammatory mediator, inhibits CD163 expression =-=[30]-=-. Growth factors which induce differentiation of monocytes into macrophages, such as macrophage colony stimulating factor (M-CSF), enhance CD163 expression, while those inducing differentiation of mon...
6	Moestrup SK, De Keyser F. Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondyloarthropathy synovitis. Arthritis Rheum - Baeten, HJ, et al. (Show Context) Citation Context ...of tissue macrophages [13, 40–44]. Moreover, detectable levels of sCD163 in body fluids such as the synovial fluid of patients with rheumatoid arthritis or with spondyloarthropathy have been reported =-=[36, 45]-=-. The main mechanism responsible for the appearance of sCD163 in body fluids is thought to be shedding of CD163 from the cell surface of mononuclear phagocytes [29, 32]. At least two enzymes have been...
6	Bruggen R, Deng DM et al. The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria - BO, van (Show Context) Citation Context ...lammatory cytokines. CD163 binds not only to endogenous but also to exogenous ligands such as bacteria and viruses [56–58]. Gram-positive and gram-negative bacteria have each been shown to bind CD163 =-=[56]-=-. CD163 expressed on cell membrane as well as an immobilized protein efficiently binds bacteria. A peptide motif, GRIEIKFQGRW, located within the second SRCR domain of CD163, has been shown to be the ...
6	Doorsselaere J, Delputte PL, Nauwynck HJ. Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus - Gorp, Breedam, et al. (Show Context) Citation Context .... A series of mutation and genetic recombination studies have demonstrated that the fifth, but not the first, second or ninth, SRCR domain of CD163 is crucial for binding and internalization of PPRSV =-=[62]-=-. Altogether, studies strongly support the notion that membrane-bound CD163 functions as a receptor for endogenous and exogenous ligands, thereby participating in the initiation and/or perpetuation of...
5	A mAb to a novel differentiation antigen on human macrophages associated with the down-regulatory phase of the inflammatory process. Exp Cell Biol - Zwadlo, Voegeli, et al. - 1987 (Show Context) Citation Context ...alveolar macrophages [12, 20]. The level of expression of CD163 on tissue macrophages has been shown to increase during the resolution of acute inflammatory response or during the wound healing phase =-=[21, 22]-=-. Neither granulocytes nor dendritic cells express significant levels of CD163. Expression of CD163 also depends on the maturation stage of monocytes/macrophages. To date, only one monocytic cell line...
5	Tsianakas A et al. Glucocorticoids induce an activated, anti-inflammatory monocyte subset in mice that resembles myeloid-derived suppressor cells - Varga, Ehrchen
5	Erpenstein U, Rohdewald P, Sorg C. Biochemical characterization of a glucocorticoid-induced membrane protein (RM3/1) in human monocytes and its application as a model system for ranking glucocorticoid potency. Pharm Res - Hogger - 1998 (Show Context) Citation Context ...ocyte/macrophage CD163 expression after shedding of the receptor in response to Toll like receptor (TLR) stimulation [27, 28]. Glucocorticoids are at least equally potent inducers of CD163 expression =-=[16, 26]-=-. The magnitude of up-regulation of CD163 expression depends on the potency of the glucocorticoid: those having the greatest affinity for the glucocorticoid receptor are the most potent for up-regulat...
5	Moller HJ, Moestrup SK. Tumor necrosis factor alpha – converting enzyme (TACE/ /ADAM17) mediates ectodomain shedding of the scavenger receptor CD163 - Etzerodt, MB, et al. (Show Context) Citation Context ...y monocytes/macrophage cells [28]. This down-regulation of CD163 expression is caused by shedding of CD163 from the cell surface, which has been shown to involve a metalloproteinase-dependent process =-=[29, 32]-=-. The same mechanism is responsible for down-regulation of monocyte CD163 expression by oxidative stress or 8-iso-prostaglandin F2a [33]. Prolonged stimulation with cell membrane TLR agonists, however...
5	Moestrup SK, Kritharides L. The monocytic lineage specific soluble CD163 is a plasma marker of coronary atherosclerosis. Atherosclerosis - LP, HJ, et al.
5	Hogger P. Interaction of soluble CD163 with activated T lymphocytes involves its association with non-muscle myosin heavy chain type A. Immunol Cell Biol - Timmermann, Buck, et al. (Show Context) Citation Context ...e form, as membrane-bound CD163 does not exert such an effect [64]. The interaction between sCD163 and T lymphocytes is mediated by binding of sCD163 to non-muscle myosin heavy chain in T lymphocytes =-=[65]-=-. The associations between T cell proliferation and CD163 also come from in vivo studies in which elevated tissue expression of sCD163 is found in places where T cell proliferation is attenuated [66]....
4	HJ, Moestrup SK. Hemoglobin and heme scavenger receptors. Antioxid Redox Signal - DP, Moller (Show Context) Citation Context ...lar metabolism within the lysosomes [52]. The heme undergoes intracellular degradation by the rate-limiting enzyme heme oxygenase-1 (HO-1), giving rise to free iron, biliverdine and carbon oxide (CO) =-=[49, 53]-=-. Altogether, the interaction of Hb-Hp with CD163 leads to release of IL-10 and CO, which exert strong anti-inflammatory effects. The release of IL-10 and CO by macrophages in response to binding of H...
4	Cardo-Vita M, Kuniyasu A et al. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications - LC (Show Context) Citation Context ... a combinatorial peptide library designed to search for a tumor necrosis factor-like weak inducer of apoptosis (TWEAK, TNFS12) ligands led to the discovery of motifs similar to those present in CD163 =-=[54]-=-. The discovery was reinforced by direct protein-protein interaction experiments, which showed that TWEAK specifically binds to CD163 [54]. TWEAK is a member of the TNF superfamily and plays many impo...
4	Vorlolomeev E, Kischkel F et al. TWEAK attenuates the transition from innate to adaptive immunity. Cell - Maecker (Show Context) Citation Context ...roliferation, apoptosis and angiogenesis [59]. Its ability to regulate innate and adaptive immune response seems to be one of the most interesting aspects of TWEAK from an immunological point of view =-=[60]-=-. In mice with genetically silenced TWEAK (TWEAK –/–), systemic administration of LPS results in a stronger inflammatory response with greater production of IFN-g and IL-12, but with less IL-10 than i...
3	Guyre PM. Cross-linking of FcgammaR triggers shedding of the hemoglobin-haptoglobin scavenger receptor CD163 - TH, PA, et al. (Show Context) Citation Context ...nists [28]. Activation of intracellular TLRs does not, however, affect CD163 expression. Other factors which down-regulate CD163 expression include hypoxia and crosslinking of Fcgamma receptor (FcgR) =-=[34, 35]-=-. Hypoxia leads to inhibition of CD163 at the transcriptional level, while cross-linking of FcgR results in shedding of CD163 from the cell surface [34, 35]. Immunoglobulin G immobilized on a culture ...
3	de Fost M, Aerts H, Hollak C, Moestrup SK. Plasma level of the macrophage-derived soluble CD163 is increased and positively correlates with severity in Gaucher’s disease - HJ
3	T et al. Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis. Arthritis Res Ther. 2010;12:R128. Submitted: 16 May, 2011 Accepted after reviews: 16 - Higashi-Kuwata, Jinnin, et al. - 2011 (Show Context) Citation Context ...3 on skin macrophages and peripheral blood monocytes from patients with systemic sclerosis (scleroderma), an autoimmune disease characterized by local inflammatory infiltrates and widespread fibrosis =-=[68]-=-. The role of increased CD 163 in the pathogenesis of systemic sclerosis remains to be established. Perspectives Evaluation of CD163 expression would appear to be an interesting avenue in the assessme...
2	Pietruczuk M, Dabrowska M, Bodzenta-Lukaszyk A. Monocyte CD163 and CD36 expression in human whole blood and isolated mononuclear cell samples: influence of different anticoagulants. Clin Vaccin Immunol - Moniuszko, Kowal, et al.
2	R et al. Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3. Clin Exp Immunol - Matushita, Kashiwagi, et al. (Show Context) Citation Context ...of tissue macrophages [13, 40–44]. Moreover, detectable levels of sCD163 in body fluids such as the synovial fluid of patients with rheumatoid arthritis or with spondyloarthropathy have been reported =-=[36, 45]-=-. The main mechanism responsible for the appearance of sCD163 in body fluids is thought to be shedding of CD163 from the cell surface of mononuclear phagocytes [29, 32]. At least two enzymes have been...
2	HJ, DuBuske LM, Moestrup SK, Bodzenta-Łukaszyk A. Differential expression of monocyte CD163 in single- and dual-asthmatic responders during allergen-induced bronchoconstriction. Clin Exp Allergy - Kowal, Moller (Show Context) Citation Context ...ry, asthmatic patients who did not develop late asthmatic response after allergen challenge were characterized by elevated concentrations of plasma sCD163 and an increase in monocyte CD163 expression =-=[37]-=-. Resolution of inflammatory response after allergen exposure is, therefore, associated with high plasma sCD163 concentrations, which is in line with original descriptions of elevated CD163 expression...
2	Serum levels of soluble CD163 correlate with the inflammatory process in coeliac disease. Aliment Pharmacol Ther - DA, Walsh, et al.
2	Kronborg G et al. Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients. Clin Microbiol Infect - TB, Gustafson
2	Haubeck HD, Sorg C, Schmutzler W. Glucocorticoid-induced appearance of the macrophage subtype RM3/1 in peripheral blood of man. Int Arch Allergy Appl Immunol - Zwadlo-Klarwasser, Bent - 1990 (Show Context) Citation Context ... be the main mechanism affecting sCD163 levels. Intravenous administration of hydrocortisone to healthy volunteers resulted in enhanced CD163 mRNA and protein expression on peripheral blood monocytes =-=[46, 47]-=-. Elevated numbers of CD163+ monocytes have been seen as soon as six hours after intravenous administration of glucocorticoids, and lasted for at least four days [46]. The maximum effect was seen betw...
2	K et al. In vivo exposure to high or low cortisol has biphasic effects on inflammatory response pathways of human monocytes. Anasth Analg - MP, PA, et al. (Show Context) Citation Context ... be the main mechanism affecting sCD163 levels. Intravenous administration of hydrocortisone to healthy volunteers resulted in enhanced CD163 mRNA and protein expression on peripheral blood monocytes =-=[46, 47]-=-. Elevated numbers of CD163+ monocytes have been seen as soon as six hours after intravenous administration of glucocorticoids, and lasted for at least four days [46]. The maximum effect was seen betw...
2	Munoz-Garcia B, Martin-Ventura JL et al. The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis. Atherosclerosis - JA
1	Sieweke MH, Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Ann Rev Immunol - Auffrey (Show Context) Citation Context ...istochemica et Cytobiologica 2011, Vol. 49, No. 3, 365–374) Key words: CD163, inflammation Introduction Monocytes and macrophages play an important role in the regulation of the inflammatory response =-=[1, 2]-=-. Based on their functional properties, at least two subpopulations (M1 and M2) of mononuclear phagocytes, which differ in their pro- and anti-inflammatory potential, have been described [3]. The cell...
1	The scavenger receptor cysteines-rich (SRCR) domain: an ancient and highly conserved protein module of the innate immune system. Crit Rev Immunol - MR, Gronlund, et al.
1	Polfliet MM, Vioet RP et al. The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor. Blood - BO (Show Context) Citation Context ...ation with protein kinase C and creatine kinase [4]. CD163 is heavily glycosylated with N-linked glycans. Treatment of CD163 with endoglycosidase F significantly reduces the molecular weight of CD163 =-=[6]-=-. Moreover, CD163 also exists as a soluble protein (sCD163) [4]. It is detectable in the plasma of healthy persons and can also be detected in body fluids such as synovial fluids [4]. It contains most...
1	Assignment of the CD163 antigen (Cd163) to mouse chromosome 6 band F2 by radiation hybrid mapping. Cytogenet Genome Res - DJ, Schoeden, et al. - 2002 (Show Context) Citation Context ...been described [7, 8]. Murine CD163 is highly homologous to human CD163 [10]. The gene encoding mouse CD163 is located on chromosome 6 in close proximity to complement components 1r and 1s and to CD9 =-=[11]-=-. That location is homologous to the gene cluster on human chromosome 12p13.3, which contains the human CD163 gene. Like human CD163, mouse CD163 is a type I transmembrane protein which contains a sho...
1	Rassias AJ, Wardwell K et al. Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163 - KA (Show Context) Citation Context ... IL-1a, IL-1b or chemokines such as CXCL-8 (IL-8) decrease expression of CD163 [16]. Similarly, exogenous pro-inflammatory molecules such as lipopolysaccharide (LPS) also decrease expression of CD163 =-=[28, 29]-=-. Interestingly, not only a Th-1 type cytokine (interferon-gamma; IFN-g) but also Th-2 type cytokines (IL-4 and IL-13) down-regulate CD163 expression [16]. These cytokines can suppress not only up-reg...
1	Guyre PM. TGF-b regulation of human macrophage scavenger receptor CD163 is Smad3-dependent - PA, KE, et al. (Show Context) Citation Context ...exerts pro- and anti-inflammatory effects on mononuclear phagocytes, enhances expression of CD163 [18]. Several chemokines have also been reported to affect CD163 expression on mononuclear phagocytes =-=[16, 31]-=-. CCL-3 (MIP-1a) and CXCL-8 down-regulate spontaneous and glucocorticoid-induced CD163 expression on cultured human monocytes [16]. Monocytes cultured in vitro in the presence of CXCL-4 express less C...
1	Vloet RP et al. Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis - BO, HJ (Show Context) Citation Context ...n association between plasma MMP-9 levels and plasma sCD163 concentrations has been demonstrated in multiple sclerosis patients, supporting a role of MMP-9 in the regulation of CD163 shedding in vivo =-=[38]-=-. Several alternative splice variants of CD163 mRNA, which code for truncated forms of CD163 protein, have been reported. The transcriptional and/or translational regulation of CD163 expression does n...
1	TB et al. Diagnostic value of soluble CD163 serum levels in patients suspected of meningitis: comparison with CRP and procalcitonin - TB, Larsen, et al.
1	Nielsen MJ et al. Molecular characterization of the haptoglobin-hemoglobin receptor CD163 - Madsen, HJ (Show Context) Citation Context ...hen released from erythrocytes, Hb binds to Hp to form complexes containing at least two Hb molecules. Formation of these complexes results in exposure of a new epitope, which allows binding to CD163 =-=[50, 51]-=-. The binding site for Hb-Hp complexes is located within the 3 SRCR domain, and the binding process is both a calciumand pH-dependent phenomenon [50, 51]. When calcium concentration is below 0.5 mM, o...
1	Kurrer MD, Schaer DJ. Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages. Circ Res - CA, Schoedon, et al. (Show Context) Citation Context ...163 complex is internalized and Hb-Hp is delivered to early endosomes, where CD163 dissociates and recycles to the plasma membrane, while Hb-Hp undergoes intracellular metabolism within the lysosomes =-=[52]-=-. The heme undergoes intracellular degradation by the rate-limiting enzyme heme oxygenase-1 (HO-1), giving rise to free iron, biliverdine and carbon oxide (CO) [49, 53]. Altogether, the interaction of...
1	Gomez-Puertas P, Gomez-del-Moral M et al. Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection. Arch Virol - Sanchez-Torrez (Show Context) Citation Context ...including fibroblasts, endothelial cells and epithelial cells, release a broad range of chemokines, pro-inflammatory cytokines and matrix metalloproteinases (MMPs) in response to stimulation by TWEAK =-=[57]-=-. Monocytes express little or no Fn14 [54, 59]. They do, however, bind specifically TWEAK, and CD163 is responsible for that binding [54]. Further experiments revealed that the TWEAK binding site on C...
1	A brief review of CD163 and its role in PPRSV infection. Virus Res. 2010; epub - SKW, JG (Show Context) Citation Context ...eptibility to infection for both viruses is proportional to the expression of CD163 on the cell surface [57, 58], and the viruses have a very restricted cell tropism for the monocyte/macrophage cells =-=[57, 58, 61]-=-. In a study of swine bone marrow monocyte precursors, peripheral blood monocytes and alveolar macrophages, the susceptibility of infection by ASFV was dependent on the degree of maturation of mononuc...
1	Lapperre TS, Snoeck-Stroband JB et al. Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD. Respir Res - LIZ (Show Context) Citation Context ...o allergen challenge. In chronic obstructive pulmonary disease (COPD), substantial expression of CD163 has been demonstrated on macrophages derived from bronchoalveolar lavage (BAL) or induced sputum =-=[67]-=-. Smoking cessation leads polarization of macrophages towards an anti-inflammatory phenotype, which is reflected by a higher percentage of macrophages expressing CD163 in BAL derived from ex-smokers. ...