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Abstract: We describe a method of implementing efficient computer simulations of immune systems that have a large number of unique B and/or T cell clones. The method uses an implementation technique called lazy evaluation to create the illusion that all clones are being simulated, while only actually simulating a much smaller number of clones that can respond to the antigens in the simulation. The method is effective because only 0.001% to 0.01% of clones can typically be stimulated by an antigen, and... (Update)
Context of citations to this paper: More
.... s Sparse Distributed Memory [30] and applied the model to the problem of vaccine design for mutating viruses, focusing on in uenza [44, 45, 46, 49]. Smith s computational model is concerned with B cells, plasma cells, antibodies, memory B cells, and antigens. The model is...
...as simple and efficient as possible without sacrificing essential aspects of the immune response. Using techniques such as lazy evaluation [40] allows models to instantiate only cells that participate in an immune response, but a response in a mouse can involve on the order of...
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BibTeX entry: (Update)
Smith, D. J., S. Forrest, D. H. Ackley, and A. S. Perelson. \Using Lazy Evaluation to Simulate Realistic-Size Repertoires in Models of the Immune System." Bull. Math. Biol. 60 (1998): 647-658. http://citeseer.ist.psu.edu/smith98using.html More
@inproceedings{ smith98using,
author = "Sean W. Smith and Elaine R. Palmer and Steve Weingart",
title = "Using a High-Performance, Programmable Secure Coprocessor",
booktitle = "Financial Cryptography",
pages = "73-89",
year = "1998",
url = "citeseer.ist.psu.edu/smith98using.html" }
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Documents on the same site (http://www.cs.unm.edu/~dsmith/recent-publications.html): More
Modeling the Effects of Prior Infection on Vaccine Efficacy - Derek Smith (Correct)
Deriving Shape Space Parameters from Immunological Data - Smith, al. (Correct)
Immunological Memory is Associative - Smith, Forrest, al. (1996) (Correct)
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