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Magnetic field exposure increases cell proliferation but does not affect melatonin levels in the mammary gland of female Sprague-Dawley rats
- Cancer Res
, 2002
"... In line with the possible relationship between electric power and breast cancer risk as well as the underlying “melatonin hypothesis, ” we have shown previously (Thun-Battersby et al., Cancer Res., 59: 3627–3633, 1999) that 50-Hz magnetic fields (MFs) of low (100 Tesla) flux density enhance mammary ..."
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In line with the possible relationship between electric power and breast cancer risk as well as the underlying “melatonin hypothesis, ” we have shown previously (Thun-Battersby et al., Cancer Res., 59: 3627–3633, 1999) that 50-Hz magnetic fields (MFs) of low (100 Tesla) flux density enhance mammary gland tumor development and growth in the 7,12-dimethylbenz(a)anthracene model of breast cancer in female Sprague Dawley rats. On the basis of the melatonin hypothesis and previous observations of induction of ornithine decarboxylase in response to MF, we proposed that the effect of MF exposure on mammary carcinogenesis is related to enhanced proliferation of the mammary epithelium. The objective of the present study was to directly assess this proposal by the use of proliferation markers. Female Sprague Dawley rats were MF or sham exposed for 2 weeks at a flux density of 100 Tesla. Proliferation of epithelial cells in the mammary tissue and adjacent skin was examined by
Interactions of zero-frequency and oscillating magnetic fields with biostructures and biosystems
, 2002
"... This review points to the investigations concerning the effects of zero-frequency (DC) and oscillating (AC) magnetic fields (MFs) on living matter, and especially those exerted by weak DC and low-frequency/low-intensity AC MFs. Starting from the analysis of observations on the action of natural magn ..."
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This review points to the investigations concerning the effects of zero-frequency (DC) and oscillating (AC) magnetic fields (MFs) on living matter, and especially those exerted by weak DC and low-frequency/low-intensity AC MFs. Starting from the analysis of observations on the action of natural magnetic storms (MSs) or periodic geomagnetic field (GMF) variations on bacteria, plants and animals, which led to an increasing interest in MFs in general, this survey pays particular attention to the background knowledge regarding the action of artificial MFs not only at the ionic, molecular or macromolecular levels, but also at the levels of subcellular regions, in vitro cycling cells, in situ functioning tissues or organs and total bodies or entire populations. The significance of some crucial findings concerning, for instance, the MFdependence of the nuclear or cellular volumes, rate of cell proliferation vs. that of cell death, extent of necrosis vs. that of apoptosis and cell membrane fluidity, is judged by comparing the results obtained in a solenoid (SLD), where an MF can be added to a GMF, with those obtained in a magnetically shielded room (MSR), where the MFs can be partially attenuated or null. This comparative criterion is required because the differences detected in the behaviour of the experimental samples against that of the controls are rather small per se and also because the evaluation of the data often depends upon the peculiarity of the methodologies used. Therefore, only very small differences are observed in estimating the MF-dependence of the expression of a single gene or of the rates of total DNA replication, RNA transcription and protein translation. The review considers the MF-dependence of the interactions between host eukaryotic cells and infecting bacteria, while documentation of the harmful effects of the MFs on specific life processes is reported; cases of favourable action of the MFs on a number of biological functions are also evidenced. In the framework of studies on the origin and adaptation of life on Earth or in the Universe, theoretical insights paving the way to elucidate
Effects of Exposure to Extremely Low-Frequency Magnetic Field of
, 2002
"... In the present study, we examined the effects of chronic exposure (1 and 2 weeks) to an extremely low-frequency magnetic field (ELFMF) of 2 G intensity on memory in rats using an object recognition task. Comparable groups of rats were exposed for 1, 2 or 4 weeks to ELFMF and the following day blood ..."
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In the present study, we examined the effects of chronic exposure (1 and 2 weeks) to an extremely low-frequency magnetic field (ELFMF) of 2 G intensity on memory in rats using an object recognition task. Comparable groups of rats were exposed for 1, 2 or 4 weeks to ELFMF and the following day blood samples were collected from each rat for the measurement of corticosterone level. Our results demonstrate that exposure to ELFMF induces a significant increase in the level of corticosterone in blood plasma and is associated with impairment in discrimination between familiar and novel objects. D 2002 Elsevier Science Inc. All rights reserved.
Deficits in Water Maze Performance and Oxidative Stress in the Hippocampus and Striatum Induced by Extremely Low Frequency Magnetic Field Exposure
, 2012
"... The exposures to extremely low frequency magnetic field (ELF-MF) in our environment have dramatically increased. Epidemiological studies suggest that there is a possible association between ELF-MF exposure and increased risks of cardiovascular disease, cancers and neurodegenerative disorders. Animal ..."
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The exposures to extremely low frequency magnetic field (ELF-MF) in our environment have dramatically increased. Epidemiological studies suggest that there is a possible association between ELF-MF exposure and increased risks of cardiovascular disease, cancers and neurodegenerative disorders. Animal studies show that ELF-MF exposure may interfere with the activity of brain cells, generate behavioral and cognitive disturbances, and produce deficits in attention, perception and spatial learning. Although, many research efforts have been focused on the interaction between ELF-MF exposure and the central nervous system, the mechanism of interaction is still unknown. In this study, we examined the effects of ELF-MF exposure on learning in mice using two water maze tasks and on some parameters indicative of oxidative stress in the hippocampus and striatum. We found that ELF-MF exposure (1 mT, 50 Hz) induced serious oxidative stress in the hippocampus and striatum and impaired hippocampal-dependent spatial learning and striatum-dependent habit learning. This study provides evidence for the association between the impairment of learning and the oxidative stress in
Extremely low-frequency electromagnetic fields exposure and female breast cancer risk: A metaanalysis based on 24,338 cases and 60,628 controls. Breast Cancer Res Treat 123(2):569–576
, 2010
"... Abstract Exposure to extremely low-frequency electromagnetic fields (ELF-EMF) has been suggested to increase female breast cancer risk; however, the data have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, ..."
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Abstract Exposure to extremely low-frequency electromagnetic fields (ELF-EMF) has been suggested to increase female breast cancer risk; however, the data have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, the Cochrane Library and Web of Science were searched. Crude ORs with 95% CIs were used to assess the strength of association between ELF-EMF exposure and female breast cancer risk. A total of 15 studies published over the period 2000 to 2009 including 24,338 cases and 60,628 controls were involved in this meta-analysis. The results showed no significant association between ELF-EMF exposure and female breast cancer risk in total analysis (OR = 0.988, 95% CI = 0.898-1.088) and in all the subgroup analyses by exposure modes, menopausal status, and estrogen receptor status. This result is in accordance with the previous meta-analysis carried out by Erren in 2000. In conclusion, this meta-analysis suggests that ELF-EMF exposure has no association with the susceptibility of female breast cancer.
Exposure to GSM RF Fields Does Not Affect Calcium Homeostasis in Human Endothelial Cells, Rat Pheocromocytoma Cells or Rat Hippocampal Neurons
"... In the course of modern daily life, individuals are exposed to numerous sources of electromagnetic radiation that are not present in the natural environment. The strength of the electromagnetic fields from sources such as hairdryers, computer display units and other electrical devices is modest. How ..."
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In the course of modern daily life, individuals are exposed to numerous sources of electromagnetic radiation that are not present in the natural environment. The strength of the electromagnetic fields from sources such as hairdryers, computer display units and other electrical devices is modest. However, in many home and office environments, individuals can experience perpetual exposure to an ‘‘electromagnetic smog’’, with occasional peaks of relatively high electromagnetic field intensity. This has led to concerns that such radiation can affect health. In particular, emissions from mobile phones or mobile phone masts have been invoked as a potential source of pathological electromagnetic radiation. Previous reports have suggested that cellular calcium (Ca 2+) homeostasis is affected by the types of radiofrequency fields emitted by mobile phones. In the present study, we used a high-throughput imaging platform to monitor putative changes in cellular Ca 2+ during exposure of cells to 900 MHz GSM fields of differing power (specific absorption rate 0.012–2 W/Kg), thus mimicking the type of radiation emitted by current mobile phone handsets. Data from cells experiencing the 900 Mhz GSM fields were compared with data obtained from paired experiments using continuous wave fields or no field. We employed three cell types (human endothelial cells, PC-12 neuroblastoma and primary hippocampal neurons) that have previously been suggested to be sensitive to radiofrequency fields. Experiments were designed to examine putative effects of radiofrequency fields on resting Ca 2+, in addition to Ca 2+ signals evoked by an InsP3-generating agonist. Furthermore,
EFFECT OF COMBINED TREATMENT WITH PAROXETINE AND TRANSCRANIAL MAGNETIC STIMULATION (TMS) ON THE MITOGEN-INDUCED PROLIFERATIVE RESPONSE OF RAT LYMPHOCYTES
"... Effect of combined treatment with paroxetine and transcranial magnetic stimulation (TMS) on the mitogen-induced proliferative response of rat lymphocytes. ..."
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Effect of combined treatment with paroxetine and transcranial magnetic stimulation (TMS) on the mitogen-induced proliferative response of rat lymphocytes.
Electroendocytosis: exposure of cells to pulsed electric fields enhanches adsorption and uptake of macromolecules, Biophys
- J
"... All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately. ..."
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All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.
AN IN VIVO STUDY OF THE IMPACT OF 4MT STATIC MAGNETIC FIELD TO MODIFY THE DIFFERENTIATION RATE OF RAT BONE MARROW STEM CELLS INTO
"... Natural magnetic fields (MFs) vary over the earth's surface based on the geographic longitude and latitude of the locations between 0.035 and 0.07 mT. This natural MF is sensed by certain animals that ..."
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Natural magnetic fields (MFs) vary over the earth's surface based on the geographic longitude and latitude of the locations between 0.035 and 0.07 mT. This natural MF is sensed by certain animals that
Sex hormone status in male rats after exposure to 50 Hz, 5 mTesla magnetic field
- Archives of Andrology
, 2006
"... Sex hormone status in male rats after exposure to 50 Hz, 5 mTesla magnetic field ..."
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Sex hormone status in male rats after exposure to 50 Hz, 5 mTesla magnetic field