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Q (2009) ‘Runxs and regulations’ of sensory and motor neuron subtype differentiation: implications for hematopoietic development. Blood Cells Mol Dis 43
"... Runt-related (RUNX) transcription factors are evolutionarily conserved regulators of a number of developmental mechanisms. RUNX proteins often control the balance between proliferation and differentiation and alterations of their functions are associated with different types of cancer and other huma ..."
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Runt-related (RUNX) transcription factors are evolutionarily conserved regulators of a number of developmental mechanisms. RUNX proteins often control the balance between proliferation and differentiation and alterations of their functions are associated with different types of cancer and other human pathologies. Moreover, RUNX factors control important steps during the developmental acquisition of mature phenotypes. A number of investigations are beginning to shed light on the involvement of RUNX family members in the development of the nervous system. This review summarizes recent progress in the study of the roles of mammalian RUNX proteins during the differentiation of sensory and motor neurons in the peripheral and central nervous system, respectively. The implications of those findings for RUNX-mediated regulation of hematopoietic development will also be discussed.
Modeling bistable cell-fate choices in the drosophila eye: qualitative and quantitative perspectives. Development 137
, 2010
"... A major goal of developmental biology is to understand the molecular mechanisms whereby genetic signaling networks establish and maintain distinct cell types within multicellular organisms. Here, we review cell-fate decisions in the developing eye of Drosophila melanogaster and the experimental resu ..."
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A major goal of developmental biology is to understand the molecular mechanisms whereby genetic signaling networks establish and maintain distinct cell types within multicellular organisms. Here, we review cell-fate decisions in the developing eye of Drosophila melanogaster and the experimental results that have revealed the topology of the underlying signaling circuitries. We then propose that switchlike network motifs based on positive feedback play a central role in cell-fate choice, and discuss how mathematical modeling can be used to understand and predict the bistable or multistable behavior of such networks.
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"... The human disease acute myelogenous leukemia (AML) is characterized by the proliferation of undifferentiated hematopoietic precursor cells. The most common chromosomal abnormality associated with AML is a ..."
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The human disease acute myelogenous leukemia (AML) is characterized by the proliferation of undifferentiated hematopoietic precursor cells. The most common chromosomal abnormality associated with AML is a
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"... Extensive genetic and molecular studies have elucidated the major principles of the pathway that generates the segmented body plan of the Drosophila embryo. Broad gradients of maternal information are decoded in three successive steps by ..."
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Extensive genetic and molecular studies have elucidated the major principles of the pathway that generates the segmented body plan of the Drosophila embryo. Broad gradients of maternal information are decoded in three successive steps by
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"... Extensive genetic and molecular studies have elucidated the major principles of the pathway that generates the segmented body plan of the Drosophila embryo. Broad gradients of maternal information are decoded in three successive steps by ..."
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Extensive genetic and molecular studies have elucidated the major principles of the pathway that generates the segmented body plan of the Drosophila embryo. Broad gradients of maternal information are decoded in three successive steps by
BMC Developmental Biology BioMed Central
, 2009
"... Research article Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc ..."
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Research article Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc
© 2008 BioMed Central Ltd Summary
, 2008
"... The Drosophila Groucho (Gro) protein was the founding member of the family of transcriptional co-repressor proteins that now includes the transducin-like enhancer of split (TLE) and Grorelated gene (Grg) proteins in vertebrates. Gro family proteins do not bind DNA directly, but are recruited by a di ..."
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The Drosophila Groucho (Gro) protein was the founding member of the family of transcriptional co-repressor proteins that now includes the transducin-like enhancer of split (TLE) and Grorelated gene (Grg) proteins in vertebrates. Gro family proteins do not bind DNA directly, but are recruited by a diverse profile of transcription factors, including members of the Hes, Runx, Nkx, LEF1/Tcf, Pax, Six and c-Myc families. The primary structure of Gro proteins includes five identifiable regions, of which the most highly conserved are the amino-terminal glutamine-rich Q domain and the carboxy-terminal WD-repeat domain. The Q domain contains two coiled-coil motifs that facilitate oligomerization into tetramers and binding to some transcription factors. The WD domain folds to form a β-propeller, which mediates protein-protein interactions. Many transcription factors interact with the WD domain via a short peptide motif that falls into either of two classes: WRPW and related tetrapeptides; and the ‘eh1 ’ motif (FxIxxIL). Gro family proteins are broadly expressed during development and in the adult. They have essential functions in many developmental pathways (including Notch and Wnt signaling) and are implicated in the pathogenesis of some cancers. The molecular mechanisms through which Gro proteins act to repress transcription are not yet well understood. It is becoming clear that Gro proteins have
Deadpan Contributes to the Robustness of the Notch Response
, 2013
"... Notch signaling regulates many fundamental events including lateral inhibition and boundary formation to generate very reproducible patterns in developing tissues. Its targets include genes of the bHLH hairy and Enhancer of split [E(spl)] family, which contribute to many of these developmental decis ..."
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Notch signaling regulates many fundamental events including lateral inhibition and boundary formation to generate very reproducible patterns in developing tissues. Its targets include genes of the bHLH hairy and Enhancer of split [E(spl)] family, which contribute to many of these developmental decisions. One member of this family in Drosophila, deadpan (dpn), was originally found to have functions independent of Notch in promoting neural development. Employing genome-wide chromatin-immunoprecipitation we have identified several Notch responsive enhancers in dpn, demonstrating its direct regulation by Notch in a range of contexts including the Drosophila wing and eye. dpn expression largely overlaps that of several E(spl) genes and the combined knock-down leads to more severe phenotypes than either alone. In addition, Dpn contributes to the establishment of Cut expression at the wing dorsal-ventral (D/V) boundary; in its absence Cut expression is delayed. Furthermore, over-expression of Dpn inhibits expression from E(spl) gene enhancers, but not vice versa, suggesting that dpn contributes to a feed-back mechanism that limits E(spl) gene expression following Notch activation. Thus the combined actions of dpn and E(spl) appear to provide a mechanism that confers an initial rapid output from Notch activity which becomes self-limited via feedback between the targets.
