Citation Context

...arrested to allow sufficient time for DNA repair before DNA replication or mitosis. It alsosdirectly participates in DNA repair, particularly in homologous recombination and nonhomologous end-joining =-=[25;26]-=-. It has been found that bone marrow cells in p53sdeficient mice expressed significantly reduced levels of many key genes involved in thesat Pennsylvania State U niversity on February 26, 2014 http://...

Citation Context

... sur le cancer, ces caractéristiques assez simples demeurent d’actualité. Depuissune décennie, des caractéristiques additionnelles ont été proposées telles l’inflammations[11] et le rôle des microRNA =-=[12]-=-.s4 Figure 2. Les six caractéristiques des cellules cancéreuses.sLe schéma de Hanahan et Weinberg [10] inclut six caractéristiques des cellulesscancéreuses. La nouvelle théorie propose l’intégration d...

Citation Context

...d51-mediated rate of homologous recombination as well as the homologous recombination machinery per se, such as Rad51 ATPase activity and polymerization into high-order nuclear filamentous structures =-=(27, 36)-=-. In contrast, mutp53 seems to exacerbate Rad51 promotion of homologous recombination (37, 38) perhaps because the most common p53 mutations affect the DNA binding domain, the region of wtp53 that ass...