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Increasing Hydrophobicity of Nanoparticles Intensifies Lung Surfactant Film Inhibition and Particle Retention
"... ABSTRACT: Polymeric nanoparticles (NPs) have had much focus on their ability to penetrate deep pulmonary structures as potential drug carriers. However, research on the toxicological effects of NPs is in its infancy, and interaction mechanisms are largely unknown. Studies have shown that the interac ..."
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ABSTRACT: Polymeric nanoparticles (NPs) have had much focus on their ability to penetrate deep pulmonary structures as potential drug carriers. However, research on the toxicological effects of NPs is in its infancy, and interaction mechanisms are largely unknown. Studies have shown that the interactions with pulmonary structures are heavily dependent on the physicochem-ical properties of the NPs. Here, we studied how hydrophobicity of polymeric NPs affect pulmonary surfactant biophysics in vitro. We investigated a naturally derived lung surfactant, Infasurf, mixed with three polymeric NPs with varying hydrophobicities through the use of a Langmuir trough and atomic force microscopy to probe the intricacies at the air−water interface. In addition, a novel technique, constrained drop surfactometer (CDS), was used to gain insight on how NPs affect surfactant under physiological conditions. We found that the CDS can be used as a sensitive precautionary tool for identifying surfactant inhibition by NPs. Our data suggest that increasing surface hydrophobicity of NPs yields more retention in the surfactant monolayer and a higher degree of surfactant inhibition.
RESEARCH ARTICLE Acute Inflammatory Responses of Nanoparticles in an Intra-Tracheal Instillation Rat Model
"... Exposure to hard metal tungsten carbide cobalt (WC-Co) “dusts ” in enclosed industrial envi-ronments is known to contribute to the development of hard metal lung disease and an in-creased risk for lung cancer. Currently, the influence of local and systemic inflammation on disease progression followi ..."
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Exposure to hard metal tungsten carbide cobalt (WC-Co) “dusts ” in enclosed industrial envi-ronments is known to contribute to the development of hard metal lung disease and an in-creased risk for lung cancer. Currently, the influence of local and systemic inflammation on disease progression following WC-Co exposure remains unclear. To better understand the relationship betweenWC-Co nanoparticle (NP) exposure and its resultant effects, the acute local pulmonary and systemic inflammatory responses caused by WC-Co NPs were explored using an intra-tracheal instillation (IT) model and compared to those of CeO2 (another occupational hazard) NP exposure. Sprague-Dawley rats were given an IT dose (0-500 μg per rat) of WC-Co or CeO2 NPs. Following 24-hr exposure, broncho-alveolar la-vage fluid and whole blood were collected and analyzed. A consistent lack of acute local pulmonary inflammation was observed in terms of the broncho-alveolar lavage fluid param-eters examined (i.e. LDH, albumin, and macrophage activation) in animals exposed to WC-Co NP; however, significant acute pulmonary inflammation was observed in the CeO2 NP group. The lack of acute inflammation following WC-Co NP exposure contrasts with earlier
Review Paper Realistic Exposure Methods for Investigating the Interaction of Nanoparticles with the Lung at the Air-Liquid Interface In
, 2011
"... Abstract: In light of the increasingly abundant use of engineered nanoparticles (NPs) and the ongoing exposure to ambient ultrafine particles it is imperative that the potential for NPs to elicit adverse effects on human health is understood. In order to determine the potential harm that NPs may exe ..."
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Abstract: In light of the increasingly abundant use of engineered nanoparticles (NPs) and the ongoing exposure to ambient ultrafine particles it is imperative that the potential for NPs to elicit adverse effects on human health is understood. In order to determine the potential harm that NPs may exert, many different in vitro systems have been used. Commonly in vitro nanotoxicology studies use NP suspensions applied directly to cell cultures. Although the use of in vitro monoculture systems to assess the effects of NPs on, for example, the lung is frequently debated, the use of suspension exposures is not realistic in relation to the exposure of NPs to humans via inhalation; the primary31 exposure route to the human body for NPs. As an alternative to the suspension (or submerged) exposure method, numerous different exposure systems at the air-liquid interface have been developed and used in nanotoxicology research, which mimic the realistic conditions of NP inhalation exposure. In addition, such air-liquid exposure systems also offer the advantage to determine the exact dose (or concentration) which is deposited on the cell surface. The aim
Chemistry Central Journal
, 2009
"... Research article Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation ..."
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Research article Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation
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, 2013
"... This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Rat pulmonary responses to inhaled nano-TiO2: effect of primary particle size and agglomeration state ..."
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This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Rat pulmonary responses to inhaled nano-TiO2: effect of primary particle size and agglomeration state
COMMENTARY Open Access
"... Pulmonary surfactant is indispensable in order to simulate the in vivo situation ..."
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Pulmonary surfactant is indispensable in order to simulate the in vivo situation
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, 2008
"... Respiratory Research This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose ..."
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Respiratory Research This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose
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, 2009
"... PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation ..."
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PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation
International Journal of Nanomedicine Dovepress submit your manuscript | www.dovepress.com
"... Development of taiwan’s strategies for regulating nanotechnology-based pharmaceuticals harmonized with international considerations ..."
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Development of taiwan’s strategies for regulating nanotechnology-based pharmaceuticals harmonized with international considerations
