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Generalized Tensor-Based Morphometry of HIV/AIDS Using Multivariate Statistics on Deformation Tensors
"... Abstract—This paper investigates the performance of a new multivariate method for tensor-based morphometry (TBM). Statistics on Riemannian manifolds are developed that exploit the full information in deformation tensor fields. In TBM, multiple brain images are warped to a common neuroanatomical temp ..."
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Abstract—This paper investigates the performance of a new multivariate method for tensor-based morphometry (TBM). Statistics on Riemannian manifolds are developed that exploit the full information in deformation tensor fields. In TBM, multiple brain images are warped to a common neuroanatomical template via 3-D nonlinear registration; the resulting deformation fields are analyzed statistically to identify group differences in anatomy. Rather than study the Jacobian determinant (volume expansion factor) of these deformations, as is common, we retain the full deformation tensors and apply a manifold version of Hotelling’s 2 test to them, in a Log-Euclidean domain. In 2-D and 3-D magnetic resonance imaging (MRI) data from 26 HIV/AIDS patients and 14 matched healthy subjects, we compared multivariate tensor analysis versus univariate tests of simpler tensor-derived indices: the Jacobian determinant, the trace, geodesic anisotropy, and eigenvalues of the deformation tensor, and the angle of rotation of its eigenvectors. We detected consistent, but more extensive patterns of structural abnormalities, with multivariate tests on the full tensor manifold. Their improved power was established by analyzing cumulative-value plots using false discovery rate (FDR) methods, appropriately controlling for false positives. This increased detection sensitivity may empower drug trials and large-scale studies of disease that use tensor-based morphometry. Index Terms—Brain, image analysis, Lie groups, magnetic resonance imaging (MRI), statistics. I.
Deformable medical image registration: A survey
- IEEE TRANSACTIONS ON MEDICAL IMAGING
, 2013
"... Deformable image registration is a fundamental task in medical image processing. Among its most important applications, one may cite: i) multi-modality fusion, where information acquired by different imaging devices or protocols is fused to facilitate diagnosis and treatment planning; ii) longitudin ..."
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Cited by 35 (1 self)
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Deformable image registration is a fundamental task in medical image processing. Among its most important applications, one may cite: i) multi-modality fusion, where information acquired by different imaging devices or protocols is fused to facilitate diagnosis and treatment planning; ii) longitudinal studies, where temporal structural or anatomical changes are investigated; and iii) population modeling and statistical atlases used to study normal anatomical variability. In this paper, we attempt to give an overview of deformable registration methods, putting emphasis on the most recent advances in the domain. Additional emphasis has been given to techniques applied to medical images. In order to study image registration methods in depth, their main components are identified and studied independently. The most recent techniques are presented in a systematic fashion. The contribution of this paper is to provide an extensive account of registration techniques in a systematic manner.
A Continuous STAPLE for Scalar, Vector and Tensor Images: An Application to DTI Analysis
, 2009
"... The comparison of images of a patient to a reference standard may enable the identification of structural brain changes. These comparisons may involve the use of vector or tensor images (i.e. 3D images for which each voxel can be represented as an RN vector) such as Diffusion Tensor Images (DTI) or ..."
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Cited by 14 (4 self)
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The comparison of images of a patient to a reference standard may enable the identification of structural brain changes. These comparisons may involve the use of vector or tensor images (i.e. 3D images for which each voxel can be represented as an RN vector) such as Diffusion Tensor Images (DTI) or transformations. The recent introduction of the Log-Euclidean framework for diffeomorphisms and tensors has greatly simplified the use of these images by allowing all the computations to be performed on a vector-space. However, many sources can result in a bias in the images, including disease or imaging artifacts. In order to estimate and compensate for these sources of vari-ability, we developed a new algorithm, called continuous STAPLE, that estimates the reference standard underlying a set of vector images. This method, based on an Expectation-Maximization method similar in principle to the validation method STAPLE, also estimates for each image a set of parameters characterizing their bias and variance with respect to the reference standard. We demonstrate how to use these parameters for the detection of atypical images or outliers in the population under study. We identified significant differences between the tensors of diffusion images of multiple sclerosis patients and those of control subjects in the vicinity of lesions.
F-TIMER: Fast Tensor Image Morphing for Elastic Registration
"... Abstract—We propose a novel diffusion tensor imaging (DTI) registration algorithm, called fast tensor image morphing for elastic registration (F-TIMER). F-TIMER leverages multiscale tensor regional distributions and local boundaries for hierarchically driving deformable matching of tensor image volu ..."
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Cited by 9 (3 self)
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Abstract—We propose a novel diffusion tensor imaging (DTI) registration algorithm, called fast tensor image morphing for elastic registration (F-TIMER). F-TIMER leverages multiscale tensor regional distributions and local boundaries for hierarchically driving deformable matching of tensor image volumes. Registration is achieved by utilizing a set of automatically determined structural landmarks, via solving a soft correspondence problem. Based on the estimated correspondences, thin-plate splines are employed to generate a smooth, topology preserving, and dense transformation, and to avoid arbitrary mapping of nonlandmark voxels. To mitigate the problem of local minima, which is common in the estimation of high dimensional transformations, we employ a hierarchical strategy where a small subset of voxels with more distinctive attribute vectors are first deployed as landmarks to estimate a relatively robust low-degrees-of-freedom transformation. As the registration progresses, an increasing number of voxels are permitted to participate in refining the correspondence matching. A scheme as such allows less conservative progression of the correspondence matching towards the optimal solution, and hence results in a faster matching speed. Compared with its predecessor TIMER, which has been shown to outperform state-of-the-art algorithms, experimental results indicate that F-TIMER is capable of achieving comparable accuracy at only a fraction of the computation cost. Index Terms—Diffusion tensor imaging (DTI), elastic registration, log-Euclidean manifold, tensor boundaries, tensor regional distributions. I.
andN.Ayache, “Registration of 4D cardiac CT sequences under trajectory constraints with multichannel diffeomorphic demons
- IEEE Transactions on Medical Imaging
, 2010
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Surface fluid registration of conformal representation: Application to detect disease . . .
- NEUROIMAGE
, 2013
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A Kernel-based graphical model for diffusion tensor registration
- in IEEE ISBI’10
, 2010
"... registration ..."
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HARDI Denoising: Variational Regularization of the Spherical Apparent Diffusion Coefficient sADC ⋆
"... Abstract. We denoise HARDI (High Angular Resolution Diffusion Imaging) data arising in medical imaging. Diffusion imaging is a relatively new and powerful method to measure the 3D profile of water diffusion at each point. This can be used to reconstruct fiber directions and pathways in the living br ..."
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Cited by 3 (0 self)
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Abstract. We denoise HARDI (High Angular Resolution Diffusion Imaging) data arising in medical imaging. Diffusion imaging is a relatively new and powerful method to measure the 3D profile of water diffusion at each point. This can be used to reconstruct fiber directions and pathways in the living brain, providing detailed maps of fiber integrity and connectivity. HARDI is a powerful new extension of diffusion imaging, which goes beyond the diffusion tensor imaging (DTI) model: mathematically, intensity data is given at every voxel and at any direction on the sphere. However, HARDI data is usually highly contaminated with noise, depending on the b-value which is a tuning parameter preselected to collect the data. Larger b-values help to collect more accurate information in terms of measuring diffusivity, but more noise is generated by many factors as well. So large b-values are preferred, if we can satisfactorily reduce the noise without losing the data structure. We propose a variational method to denoise HARDI data by denoising the spherical
SCALAR CONNECTIVITY MEASURES FROM FAST-MARCHING TRACTOGRAPHY REVEAL HERITABILITY OF WHITE MATTER ARCHITECTURE
"... Recent advances in diffusion-weighted MRI (DWI) have enabled studies of complex white matter tissue architecture in vivo. To date, the underlying influence of genetic and environmental factors in determining central nervous system connectivity has not been widely studied. In this work, we introduce ..."
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Recent advances in diffusion-weighted MRI (DWI) have enabled studies of complex white matter tissue architecture in vivo. To date, the underlying influence of genetic and environmental factors in determining central nervous system connectivity has not been widely studied. In this work, we introduce new scalar connectivity measures based on a computationally-efficient fast-marching algorithm for quantitative tractography. We then calculate connectivity maps for a DTI dataset from 92 healthy adult twins and decompose the genetic and environmental contributions to the variance in these metrics using structural equation models. By combining these techniques, we generate the first maps to directly examine genetic and environmental contributions to brain connectivity in humans. Our approach is capable of extracting statistically significant measures of genetic and environmental contributions to neural connectivity. Index Terms — Magnetic resonance imaging, genetics, nervous system, algorithms, brain
