We consider a class of restless multi-armed bandit problems (RMBP) that arises in dynamic multichannel access, user/server scheduling, and optimal activation in multi-agent systems. For this class of RMBP, we establish the indexability and obtain Whittle’s index in closed-form for both discounted and average reward criteria. These results lead to a direct implementation of Whittle’s index policy with remarkably low complexity. When arms are stochastically identical, we show that Whittle’s index policy is optimal under certain conditions. Furthermore, it has a semi-universal structure that obviates the need to know the Markov transition probabilities. The optimality and the semi-universal structure result from the equivalency between Whittle’s index policy and the myopic policy established in this work. For non-identical arms, we develop efficient algorithms for computing a performance upper bound given by Lagrangian relaxation. The tightness of the upper bound and the near-optimal performance of Whittle’s index policy are illustrated with simulation examples.