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Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. HumMol Genet, 2013. 22(17): p. 3597–607. doi: 10.1093/hmg/ddt205 PMID: 23669352 (0)

by M Graff
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A Large-Scale Genome-Wide Interaction Study

by Thomasw. Winkler, Anne E. Justice, Mariaelisa Graff, Llilda Barata, F. Feitosa, Su Chu, Jacek Czajkowski, Tõnu Esko, Tove Fall, O. Kilpeläinen, Yingchang Lu, Reedik Mägi, Evelin Mihailov, Tune H. Pers, Sina Rüeger, Er Teumer, Georg B. Ehret, Teresa Ferreira, Rick Jansen, Charles C. White, Devin Absher, S. Ahluwalia, Shafqat Ahmad, Eva Albrecht, Er Couto Alves
"... Vol and number: 11: 10 Pages: 1-42 ..."
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...c effects. While none of these loci were associated with birth weight, all—but one—were nominally associated with increased risk of childhood obesity. Results from a GWAS on BMI in 16-to-25 year-olds =-=[58]-=- provide preliminary evidence that some loci exert their largest effects relatively early in life, whereas others become more pronounced in young adulthood. Notwithstanding the predominance of BMI loc...

RESEARCH ARTICLE The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

by Thomasw. Winkler, Anne E. Justice, Mariaelisa Graff, Llilda Barata, F. Feitosa, Su Chu, Jacek Czajkowski, Tõnu Esko, Tove Fall, O. Kilpeläinen, Yingchang Lu, Reedik Mägi, Evelin Mihailov, Tune H. Pers, Sina Rüeger, Er Teumer, Georg B. Ehret, Teresa Ferreira, L. Heard-costa, Juha Karjalainen, Vasiliki Lagou, Anubha Mahajan, D. Neinast, Inga Prokopenko, Jeannette Simino, Tanya M. Teslovich, Rick Jansen, Charles C. White, Devin Absher, S. Ahluwalia, Shafqat Ahmad, Eva Albrecht, Er Couto Alves, Jennifer L. Bragg-gresham, Anton J. M. De Craen, Joshua C. Bis, Charlestonw K. Chiang, Graciela Delgado, Ayse Demirkan, Nicole Dueker, Niina Eklund, Gudny Eiriksdottir, Joel Eriksson, Bjarke Feenstra, Krista Fischer, Francesca Frau, Tessel E. Galesloot, Frank Geller, Anuj Goel, Mathias Gorski, Tanja B. Grammer, Stefan Gustafsson, Saskia Haitjema, Jan Hottenga, Jennifer E. Huffman, Anne U. Jackson, Kevin B. Jacobs, Åsa Johansson, Marika Kaakinen, Marcus E. Kleber, Jari Lahti, Mateo Leach, Benjamin Lehne, Youfang Liu, Ken Sin Lo, Mattias Lorentzon, Pamela A. F. Madden, Barbara Mcknight, Martina Müller-nurasyid, Ilja M. Nolte, Kalliope Panoutsopoulou, Laura Pascoe, Lavinia Paternoster, Nigel W. Rayner, Frida Renström, Federica Rizzi, Lynda M. Rose, Kathy A. Ryan, Perttu Salo, Serena Sanna, Hubert Scharnagl, Jianxin Shi, Albert Vernon Smith, Lorraine Southam, Alena Stančáková, Valgerdur Steinthorsdottir, Rona J. Strawbridge, Ju Sung, Ioanna Tachmazidou, Toshiko Tanaka, Gudmar Thorleifsson
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...c effects. While none of these loci were associated with birth weight, all—but one—were nominally associated with increased risk of childhood obesity. Results from a GWAS on BMI in 16-to-25 year-olds =-=[58]-=- provide preliminary evidence that some loci exert their largest effects relatively early in life, whereas others become more pronounced in young adulthood. Notwithstanding the predominance of BMI loc...

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