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The octamer-binding transcription factor 4 (Oct-4) and stem cell literatures

by Ma Hongbao , Margaret Young , 2014
"... Abstract: The octamer is made of eight units. The octamer-binding transcription factor 4 (Oct-4) is a protein also known as POU5F1 (POU domain, class 5, transcription factor 1) encoded by the POU5F1 gene. Oct-4 is a homeodomain transcription factor of the POU family. Oct-4 is replated to animal sel ..."
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Abstract: The octamer is made of eight units. The octamer-binding transcription factor 4 (Oct-4) is a protein also known as POU5F1 (POU domain, class 5, transcription factor 1) encoded by the POU5F1 gene. Oct-4 is a homeodomain transcription factor of the POU family. Oct-4 is replated to animal self-renewal of undifferentiated embryonic stem cells. It is used as a marker for undifferentiated cells. The octamer in this family of transcription factors is the DNA nucleotide sequence "ATTTGCAT", the etymology for the naming of the octamer transcription factor.