project develops a non-invasive BCI system whose key features are (1) the use of well-established motor competences as control paradigms, (2) high-dimensional features from 128-channel EEG and (3) advanced machine learning techniques. As reported earlier, our experiments demonstrate that very high information transfer rates can be achieved using the readiness potential (RP) when predicting the laterality of upcoming left vs. right hand movements in healthy subjects. A more recent study showed that the RP similarily accompanies phantom movements in arm amputees, but the signal strength decreases with longer loss of the limb. In a complementary approach oscillatory features are used to discriminate imagined movements (left hand vs. right hand vs. foot). In a recent feedback study with 6 healthy subjects with no or very little experience with BCI control, 3 subjects achieved an information transfer rate above 35 bits per minute (bpm), and further two subjects above 24 and 15 bpm, while one subject could not achieve any BCI control. These results are encouraging for an EEG-based BCI system in untrained subjects that is independent of peripheral nervous system activity and does not rely on evoked potentials even when compared to results with very well-trained subjects operating other BCI systems.

Data recorded in EEG based Brain-Computer Interface experiments is generally very noisy, non-stationary and contaminated with artifacts, that can deteriorate discrimination/classification methods. In this work we extend the Common Spatial Pattern (CSP) algorithm with the aim to alleviate these adverse effects. In particular we suggest an extension of CSP to the state space, which utilizes the method of time delay embedding. As we will show, this allows for individually tuned frequency filters at each electrode position and thus yields an improved and more robust machine learning procedure. The advantages of the proposed method over the original CSP method are verified in terms of an improved information transfer rate (bits per trial) on a set of EEG-recordings from experiments of imagined limb movements.

Abstract — Brain-Computer Interface (BCI) systems establish a direct communication channel from the brain to an output device. These systems use brain signals recorded from the scalp, the surface of the cortex, or from inside the brain to enable users to control a variety of applications. BCI systems that bypass conventional motor output pathways of nerves and muscles can provide novel control options for paralyzed patients. One classical approach to establish EEG-based control is to set up a system that is controlled by a specific EEG feature which is known to be susceptible to conditioning and to let the subjects learn the voluntary control of that feature. In contrast, the Berlin Brain-Computer Interface (BBCI) uses well established motor competences of its users and a machine learning approach to extract subject-specific patterns from high-dimensional features optimized for detecting the user’s intent. Thus the long subject training is replaced by a short calibration measurement (20 minutes) and machine learning (1 minute). We report results from a study in which ten subjects, who had no or little experience with BCI feedback, controlled computer applications by voluntary imagination of limb movements: these intentions led to modulations of spontaneous brain activity specifically, somatotopically matched sensorimotor 7-30 Hz rhythms were diminished over pericentral cortices. The peak information transfer rate was above 35 bits per minute (bpm) for 3 subjects, above 23 bpm for two, and above 12 bpm for 3 subjects, while one subject could achieve no BCI control. Compared to other BCI systems which need longer subject training to achieve comparable results we propose that the key to quick efficiency in the BBCI system is its flexibility due to complex but physiologically meaningful features and its adaptivity which respects the enormous intersubject variability. I.

The aim of this work was to investigate the mechanisms that shape evoked electroencephalographic (EEG) and magneto-encephalographic (MEG) responses. We used a neuronally plausible model to characterise the dependency of response components on the models parameters. This generative model was a neural mass model of hierarchically arranged areas using three kinds of inter-area connections (forward, backward and lateral). We investigated how responses, at each level of a cortical hierarchy, depended on the strength of connections or coupling. Our strategy was to systematically add connections and examine the responses of each successive architecture. We did this in the context of deterministic responses and then with stochastic spontaneous activity. Our aim was to show, in a simple way, how event-related dynamics depend on extrinsic connectivity. To emphasise the importance of nonlinear interactions, we tried to disambiguate the components of event-related potentials (ERPs) or event-related fields

Abstract — Brain-Computer Interface (BCI) systems create a novel communication channel from the brain to an output device by bypassing conventional motor output pathways of nerves and muscles. Therefore they could provide a new communication and control option for paralyzed patients. Modern BCI technology is essentially based on techniques for the classification of singletrial brain signals. Here we present a novel technique that allows the simultaneous optimization of a spatial and a spectral filter enhancing discriminability rates of multi-channel EEG single-trials. The evaluation of 60 experiments involving 22 different subjects demonstrates the significant superiority of the proposed algorithm over to its classical counterpart: the median classification error rate was decreased by 11%. Apart from the enhanced classification, the spatial and/or the spectral filter that are determined by the algorithm can also be used for further analysis of the data, e.g., for source localization of the respective brain rhythms.

Cortical activity is the product of interactions among neuronal populations. Macroscopic electrophysiological phenomena are generated by these interactions. In principle, the mechanisms of these interactions afford constraints on biologically plausible models of electrophysiological responses. In other words, the macroscopic features of cortical activity can be modelled in terms of the microscopic behaviour of neurons. An evoked response potential (ERP) is the mean electrical potential measured from an electrode on the scalp, in response to some event. The purpose of this paper is to outline a population density approach to modelling ERPs. We propose a biologically plausible model of neuronal activity that enables the estimation of physiologically meaningful parameters from electrophysiological data. The model encompasses four basic characteristics of neuronal activity and organization: (i) neurons are dynamic units, (ii) driven by stochastic forces, (iii) organized into populations with similar biophysical properties and response characteristics and (iv) multiple populations interact to form functional networks. This leads to a formulation of population dynamics in terms of the Fokker–Planck equation. The solution of this equation is the temporal evolution of a probability density over state-space, representing the distribution of an ensemble of trajectories. Each trajectory corresponds to the changing state of a

Abstract: We outline the Berlin Brain-Computer Interface (BBCI), a system which enables us to translate brain signals from movements or movement intentions into control commands. The main contribution of the BBCI, which is a non-invasive EEG-based BCI system, is the use of advanced machine learning techniques that allow to adapt to the specific brain signatures of each user with literally no training. In BBCI a calibration session of about 20min is necessary to provide a data basis from which the individualized brain signatures are inferred. This is very much in contrast to conventional BCI approaches that rely on operand conditioning and need extensive subject training of the order 50-100 hours. Our machine learning concept thus allows to achieve high quality feedback already after the very first session. This work reviews a broad range of investigations and experiments that have been performed within the BBCI project. In addition to these general paradigmatic BCI results, this work provides a condensed outline of the underlying machine learning and signal processing techniques that make the BBCI succeed. In the first experimental paradigm we analyze the predictability of limb movement long before the actual movement takes place using only the movement intention measured from the pre-movement (readiness) EEG potentials. The experiments include both off-line studies and an online feedback

This paper describes a dynamic causal model (DCM) for induced or spectral responses as measured with the electroencephalogram (EEG) or the magnetoencephalogram (MEG). We model the time-varying power, over a range of frequencies, as the response of a distributed system of coupled electromagnetic sources to a spectral perturbation. The model parameters encode the frequency response to exogenous input and coupling among sources and different frequencies. The Bayesian inversion of this model, given data enables inferences about the parameters of a particular model and allows us to compare different models, or hypotheses. One key aspect of the model is that it differentiates between linear and non-linear coupling; which correspond to within and betweenfrequency coupling respectively. To establish the face validity of our approach, we generate synthetic data and test the identifiability of various parameters to ensure they can be estimated accurately, under different levels of noise. We then apply our model to EEG data from a faceperception experiment, to ask whether there is evidence for non-linear coupling between early visual cortex and fusiform areas.

A brain-computer interface (BCI) is a system that should in its ultimate form translate a subject's intent into a technical control signal without resorting to the classical neuromuscular communication channels. By using that signal to, e.g., control a wheelchair or a neuroprosthesis, a BCI could become a valuable tool for paralyzed patients. One approach to implement a BCI is to let users learn to self-control the amplitude of some of their brain rhythms as extracted from multi-channel EEG. Here we present a method that estimates subject-specific spatial filters which allow for a robust extraction of the rhythm modulations. The effectiveness of the method was proved by achieving the minimum prediction error on data set IIa in the BCI Competition 2003, which consisted of data from three subjects recorded in 10 sessions.

We propose a method for the classification of matrices. We use a linear classifier with a novel regularization scheme based on the spectral ℓ1-norm of its coefficient matrix. The spectral regularization not only provides a principled way of complexity control but also enables automatic determination of the rank of the coefficient matrix. Using the Linear Matrix Inequality technique, we formulate the inference task as a single convex optimization problem. We apply our method to the motor-imagery EEG classification problem. The method not only improves upon conventional methods in the classification performance but also determines a subspace in the signal that concentrates discriminative information without any additional feature extraction step. The method can be easily generalized to regression problems by changing the loss function. Connections to other methods are also discussed. 1.