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Editorial Biological and Clinical Significance of Androgens and Androgen Receptor in Prostate Cancer

by Shahriar Koochekpour
"... This special issue provides an update on differ-ent biological and clinical aspects of adrenal andro-gens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer (PCa). Androge ..."
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This special issue provides an update on differ-ent biological and clinical aspects of adrenal andro-gens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer (PCa). Androgen receptor (AR), a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate car-cinogenesis, and in the castrate-resistant (CR) pro-gression of PCa [1]. Understanding the critical mo-lecular events that lead PCa cells to resist antiandro-gens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease [2, 3]. In a relatively significant number of PCa
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Review Insights into Chemoresistance of Prostate Cancer

by Wei Zhang, Yan Meng, Na Liu, Xiao-fei Wen, Tao Yang
"... © 2015 Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See ..."
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© 2015 Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See
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RESEARCH ARTICLE Open Access The

by Ma Zhifang, Wei Liang, Zhang Wei, Hao Bin, Tu Rui, Wu Nan, Zhang Shuhai
"... androgen receptor plays a suppressive role in epithelial- mesenchymal transition of human prostate cancer stem progenitor cells ..."
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androgen receptor plays a suppressive role in epithelial- mesenchymal transition of human prostate cancer stem progenitor cells
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