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Androgen receptor as a driver of therapeutic resistance in advanced prostate cancer (0)

by B Kahn, J Collazo, N Kyprianou
Venue:Int J Biol Sci
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Review Insights into Chemoresistance of Prostate Cancer

by Wei Zhang, Yan Meng, Na Liu, Xiao-fei Wen, Tao Yang
"... © 2015 Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See ..."
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© 2015 Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See
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.... Androgen receptor (AR) is a nuclearshormone receptor, the discovery of which has allowedsthe identification of a subset of patients who are extremely sensitive to androgen deprivation therapys(ADT) =-=(6, 7)-=-. However, after treatment for 2–3 years,smost cases will eventually fail ADT, although somesIvyspringsInternational PublishersInt. J. Biol. Sci. 2015, Vol. 11shttp://www.ijbs.coms1161spatients will r...

Editorial Biological and Clinical Significance of Androgens and Androgen Receptor in Prostate Cancer

by Shahriar Koochekpour
"... This special issue provides an update on differ-ent biological and clinical aspects of adrenal andro-gens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer (PCa). Androge ..."
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This special issue provides an update on differ-ent biological and clinical aspects of adrenal andro-gens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer (PCa). Androgen receptor (AR), a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate car-cinogenesis, and in the castrate-resistant (CR) pro-gression of PCa [1]. Understanding the critical mo-lecular events that lead PCa cells to resist antiandro-gens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease [2, 3]. In a relatively significant number of PCa
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...s andsantiandrogens and between the antiandrogens, abiraterone and enzalutamide, as well as the therapeuticsresponses driven by the treatment sequence forsCR-PCa. In the manuscript by Kyprianou et al =-=[6]-=-, theysreview the current knowledge of the mechanisms byswhich (a) the AR signaling via regulation of epithelial-mesnchymal transition drives therapeutic resistance in CR-PCa and metastatic disease an...

RESEARCH ARTICLE Open Access The

by Ma Zhifang, Wei Liang, Zhang Wei, Hao Bin, Tu Rui, Wu Nan, Zhang Shuhai
"... androgen receptor plays a suppressive role in epithelial- mesenchymal transition of human prostate cancer stem progenitor cells ..."
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androgen receptor plays a suppressive role in epithelial- mesenchymal transition of human prostate cancer stem progenitor cells
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...S/P cells. These two kinds of cells increased, after ADT and these may common led to the failure of traditional endocrine treatment and disease progress. Androgen/androgen receptor (A/AR) axis cancer =-=[29]-=-. Now it was considered that prostate cancer cells varied, and are mainly luminal cells, but there are also some (See figure on previous page.) Figure 3 AR is a suppressor in EMT of S/P cells from LNC...

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