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Review Metallothioneins, Unconventional Proteins from Unconventional Animals: A Long Journey from Nematodes to Mammals †
, 2014
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"... stands for any amino acid, other than Cys) and metal ions2,3. These cysteine-rich proteins are localized in cytoplasm and some organelles, predominantly in mitochondria, where their presence is sensitively and strictly regulated by the oxidative state induced by mitochondrial respiration. Depending ..."
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stands for any amino acid, other than Cys) and metal ions2,3. These cysteine-rich proteins are localized in cytoplasm and some organelles, predominantly in mitochondria, where their presence is sensitively and strictly regulated by the oxidative state induced by mitochondrial respiration. Depending on the cell state, but especially presence of oxidative stress, MTs are rapidly translocated to the nucleus through nuclear pore complexes. MT localized in the nuclei is oxidized there and it is transported to cytosol; this system is balanced3. Interaction of metallothionein and metals MTs are currently classified into 15 families. Mammalian MTs are single-chain polypepti-des of 61 to 68 amino acid residues. There are no free thiol groups, and divalent metals are bound by sulfur atoms in thiolate clusters with a tetrahedral geometry (or trigonal for Cu+). Use of mass spectrometry technique (maldi-tof/tof) for the characterization of metallothionein in biological systems
American Journal of BioScience
"... Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy ..."
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Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy
